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Meena V Patel

Explore the profile of Meena V Patel including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 8
Citations 34
Followers 0
Related Specialties
Chemistry
Biochemistry
Top 10 Co-Authors
Teodozyj Kolasa
Tongmei Li
John T Randolph
Agnieszka K Bischoff
Mark A Matulenko
Julia Fitzgibbons
Adrian D Hobson
Rodger Henry
Christopher C Marvin
Axel Hernandez Jr
Published In
J Med Chem
J Org Chem
Bioorg Med Chem
Affiliations
Soon will be listed here.
Recent Articles
1.
Anti-TNF Thioester Glucocorticoid Antibody-Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model
Marvin C, Hobson A, McPherson M, Hayes M, Patel M, Schmidt D, et al.
J Med Chem . 2024 May; 67(11):9495-9515. PMID: 38780432
We describe the discovery of a thioester-containing glucocorticoid receptor modulator (GRM) payload and the corresponding antibody-drug conjugate (ADC). Payload was designed for rapid hepatic inactivation to minimize systemic exposure of...
2.
Correction to "Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate"
Hobson A, McPherson M, Hayes M, Goess C, Li X, Zhou J, et al.
J Med Chem . 2023 Apr; 66(8):6010. PMID: 37027784
No abstract available.
3.
Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate
Hobson A, McPherson M, Hayes M, Goess C, Li X, Zhou J, et al.
J Med Chem . 2022 Nov; 65(23):15893-15934. PMID: 36394224
Using a convergent synthetic route to enable multiple points of diversity, a series of glucocorticoid receptor modulators (GRM) were profiled for potency, selectivity, and drug-like properties . Despite covering a...
4.
Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Na1.7/ Nav1.8 blockers for the treatment of pain
Patel M, Peltier H, Matulenko M, Koenig J, Scanio M, Gum R, et al.
Bioorg Med Chem . 2022 Apr; 63:116743. PMID: 35436748
The voltage-gated sodium channel Na1.7 is an attractive target for the treatment of pain based on the high level of target validation with genetic evidence linking Na1.7 to pain in...
5.
Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction
Patel M, Kolasa T, Mortell K, Matulenko M, Hakeem A, Rohde J, et al.
J Med Chem . 2006 Dec; 49(25):7450-65. PMID: 17149874
The goal of this study was to identify a structurally distinct D(4)-selective agonist with superior oral bioavailability to our first-generation clinical candidate 1a (ABT-724) for the potential treatment of erectile...
6.
1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction
Kolasa T, Matulenko M, Hakeem A, Patel M, Mortell K, Bhatia P, et al.
J Med Chem . 2006 Aug; 49(17):5093-109. PMID: 16913699
A new series of dopamine D4 receptor agonists, 1-aryl-3-(4-pyridinepiperazin-1-yl)propanone oximes, was designed through the modification of known dopamine D4 receptor agonist PD 168077. Replacement of the amide group with a...
7.
Synthesis of 4,5-diaryl-1H-pyrazole-3-ol derivatives as potential COX-2 inhibitors
Patel M, Bell R, Majest S, Henry R, Kolasa T
J Org Chem . 2004 Oct; 69(21):7058-65. PMID: 15471453
4,5-Diaryl-1H-pyrazole-3-ol was utilized as a versatile template to synthesize several classes of compounds such as pyrazolo-oxazines 7, pyrazolo-benzooxazines 9, pyrazolo-oxazoles 10, and its analogues 11a-c as potential COX-2 inhibitors. Compounds...
8.
Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist
Altenbach R, Khilevich A, Kolasa T, Rohde J, Bhatia P, Patel M, et al.
J Med Chem . 2004 May; 47(12):3220-35. PMID: 15163201
Structure-activity studies were performed on the alpha(1A)-adrenoceptor (AR) selective agonist N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide (4). Compounds were evaluated for binding activity at the alpha(1A), alpha(1b), alpha(1d), alpha(2a), and alpha(2B) subtypes. Functional activity in...