Maxwell A Ruby
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Explore the profile of Maxwell A Ruby including associated specialties, affiliations and a list of published articles.
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11
Citations
392
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Recent Articles
1.
Lewis L, Chen L, Hameed L, Kitchen R, Maroteau C, Nagarajan S, et al.
JHEP Rep
. 2023 May;
5(5):100693.
PMID: 37122688
Background & Aims: Non-alcoholic fatty liver disease (NAFLD) has a prevalence of ∼25% worldwide, with significant public health consequences yet few effective treatments. Human genetics can help elucidate novel biology...
2.
Nagarajan S, Livingstone E, Monfeuga T, Lewis L, Ali S, Chandran A, et al.
Metabolism
. 2023 Apr;
144:155563.
PMID: 37088121
Background And Aim: Enhanced hepatic de novo lipogenesis (DNL) has been proposed as an underlying mechanism for the development of NAFLD and insulin resistance. Max-like protein factor X (MLX) acts...
3.
Szczerbinska I, Tessitore A, Hansson L, Agrawal A, Ragel Lopez A, Helenius M, et al.
Biomedicines
. 2022 Jan;
10(1).
PMID: 35052782
Type 2 diabetes (T2D) is a chronic metabolic disorder affecting almost half a billion people worldwide. Impaired function of pancreatic β-cells is both a hallmark of T2D and an underlying...
4.
Savikj M, Ruby M, Kostovski E, Iversen P, Zierath J, Krook A, et al.
Physiol Rep
. 2018 Jun;
6(12):e13739.
PMID: 29906337
Despite the well-known role of satellite cells in skeletal muscle plasticity, the effect of spinal cord injury on their function in humans remains unknown. We determined whether spinal cord injury...
5.
Ruby M, Riedl I, Massart J, Ahlin M, Zierath J
Am J Physiol Endocrinol Metab
. 2017 Jul;
313(4):E483-E491.
PMID: 28720584
Insulin resistance is central to the development of type 2 diabetes and related metabolic disorders. Because skeletal muscle is responsible for the majority of whole body insulin-stimulated glucose uptake, regulation...
6.
Ruby M, Massart J, Hunerdosse D, Schonke M, Correia J, Louie S, et al.
Cell Rep
. 2017 Jan;
18(3):636-646.
PMID: 28099843
Serine hydrolases are a large family of multifunctional enzymes known to influence obesity. Here, we performed activity-based protein profiling to assess the functional level of serine hydrolases in liver biopsies...
7.
Kirchner H, Sinha I, Gao H, Ruby M, Schonke M, Lindvall J, et al.
Mol Metab
. 2016 Mar;
5(3):171-183.
PMID: 26977391
Objective: Epigenetic modifications contribute to the etiology of type 2 diabetes. Method: We performed genome-wide methylome and transcriptome analysis in liver from severely obese men with or without type 2...
8.
Ruby M, Nomura D, Hudak C, Barber A, Casida J, Krauss R
PLoS One
. 2011 Nov;
6(11):e26415.
PMID: 22073164
Endocannabinoids regulate energy balance and lipid metabolism by stimulating the cannabinoid receptor type 1 (CB1). Genetic deletion and pharmacological antagonism have shown that CB1 signaling is necessary for the development...
9.
Ruby M, Goldenson B, Orasanu G, Johnston T, Plutzky J, Krauss R
J Lipid Res
. 2010 Apr;
51(8):2275-81.
PMID: 20421589
Recent evidence suggests that lipoproteins serve as circulating reservoirs of peroxisomal proliferator activated receptor (PPAR) ligands that are accessible through lipolysis. The present study was conducted to determine the biochemical...
10.
Bruss M, Khambatta C, Ruby M, Aggarwal I, Hellerstein M
Am J Physiol Endocrinol Metab
. 2009 Nov;
298(1):E108-16.
PMID: 19887594
Calorie restriction (CR) increases longevity and retards the development of many chronic diseases, but the underlying metabolic signals are poorly understood. Increased fatty acid (FA) oxidation and reduced FA synthesis...