Maximilian Hirschenberger
Overview
Explore the profile of Maximilian Hirschenberger including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
831
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Recent Articles
1.
Hirschenberger M, Lepelley A, Rupp U, Klute S, Hunszinger V, Koepke L, et al.
Nat Commun
. 2023 Nov;
14(1):6770.
PMID: 37914730
Type I interferon (IFN) signalling is tightly controlled. Upon recognition of DNA by cyclic GMP-AMP synthase (cGAS), stimulator of interferon genes (STING) translocates along the endoplasmic reticulum (ER)-Golgi axis to...
2.
Lin C, Kuffour E, Fuchs N, Gertzen C, Kaiser J, Hirschenberger M, et al.
Cell Rep
. 2023 Oct;
42(11):113277.
PMID: 37864791
Sensing of human immunodeficiency virus type 1 (HIV-1) DNA is mediated by the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling axis. Signal transduction and regulation of this cascade is...
3.
Viox E, Hoang T, Upadhyay A, Nchioua R, Hirschenberger M, Strongin Z, et al.
Sci Immunol
. 2023 Jul;
8(85):eadg0033.
PMID: 37506197
Type I interferons (IFN-I) are critical mediators of innate control of viral infections but also drive the recruitment of inflammatory cells to sites of infection, a key feature of severe...
4.
Nchioua R, Schundner A, Klute S, Koepke L, Hirschenberger M, Noettger S, et al.
Life Sci Alliance
. 2023 Mar;
6(6).
PMID: 36977594
The IFN system constitutes a powerful antiviral defense machinery. Consequently, effective IFN responses protect against severe COVID-19 and exogenous IFNs inhibit SARS-CoV-2 in vitro. However, emerging SARS-CoV-2 variants of concern...
5.
Bergner T, Zech F, Hirschenberger M, Stenger S, Sparrer K, Kirchhoff F, et al.
Viruses
. 2022 Dec;
14(12).
PMID: 36560790
Infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of the COVID-19 pandemic, leads to profound remodeling of cellular membranes, promoting viral replication and virion assembly. A...
6.
Hoang T, Viox E, Upadhyay A, Strongin Z, Tharp G, Pino M, et al.
bioRxiv
. 2022 Nov;
PMID: 36324810
Type-I interferons (IFN-I) are critical mediators of innate control of viral infections, but also drive recruitment of inflammatory cells to sites of infection, a key feature of severe COVID-19. Here,...
7.
Hirschenberger M, Stadler N, Fellermann M, Sparrer K, Kirchhoff F, Barth H, et al.
Front Pharmacol
. 2021 Nov;
12:770283.
PMID: 34733166
Translating the CRISPR/Cas9 genome editing technology into clinics is still hampered by rather unspecific, unsafe and/or inconvenient approaches for the delivery of its main components - the Cas9 endonuclease and...
8.
Hirschenberger M, Hunszinger V, Sparrer K
Cells
. 2021 Aug;
10(8).
PMID: 34440903
Non-persistent viruses classically cause transient, acute infections triggering immune responses aimed at the elimination of the pathogen. Successful viruses evolved strategies to manipulate and evade these anti-viral defenses. Symptoms during...
9.
Hirschenberger M, Hayn M, Laliberte A, Koepke L, Kirchhoff F, Sparrer K
STAR Protoc
. 2021 Aug;
2(4):100781.
PMID: 34405154
We present a protocol for analyzing the impact of SARS-CoV-2 proteins in interferon signaling using luciferase reporter assays. Here, the induction of defined promoters can be quantitatively assessed with high...
10.
Koepke L, Hirschenberger M, Hayn M, Kirchhoff F, Sparrer K
Autophagy
. 2021 Jul;
17(9):2659-2661.
PMID: 34281462
As part of innate immune defenses, macroautophagy/autophagy targets viruses and viral components for lysosomal degradation and exposes pathogen-associated molecular patterns to facilitate recognition. However, viruses evolved sophisticated strategies to antagonize...