Mauro F Azevedo
Overview
Explore the profile of Mauro F Azevedo including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
414
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Recent Articles
1.
Lima C, Verdaguer I, Wunderlich G, Katzin A, Crabb B, Gilson P, et al.
Exp Parasitol
. 2023 Sep;
254:108620.
PMID: 37716462
Conditional gene expression is a powerful tool to investigate putative vaccine and drug targets, especially in a haploid organism such as Plasmodium falciparum. Inducible systems based on regulation of either...
2.
Hoff C, Azevedo M, Thurler A, Maluf S, Melo P, Del Rivero M, et al.
Pathogens
. 2021 Nov;
10(11).
PMID: 34832608
, the most virulent of the human malaria parasite, is responsible for high mortality rates worldwide. We studied the M1 alanyl-aminopeptidase of this protozoan (PfA-M1), which is involved in the...
3.
Gabriel H, Azevedo M, Kimura E, Katzin A
Mem Inst Oswaldo Cruz
. 2018 Aug;
113(10):e180174.
PMID: 30110072
Farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key enzyme in the synthesis of isoprenic chains. Risedronate, a bisphosphonate containing nitrogen (N-BP), is a potent inhibitor of blood stage Plasmodium....
4.
Melo P, Maluf S, Azevedo M, Paschoalin T, Budu A, Bagnaresi P, et al.
Parasitol Int
. 2017 Dec;
67(2):233-236.
PMID: 29288140
Malaria is a disease caused by Plasmodium parasites that affects hundreds of millions of people. Plasmodium proteases are involved in invasion, erythrocyte egress and degradation of host proteins. Falcipains are...
5.
Budu A, Gomes M, Melo P, Maluf S, Bagnaresi P, Azevedo M, et al.
Cell Signal
. 2015 Dec;
28(3):125-135.
PMID: 26689736
Calcium and calmodulin (CaM) are important players in eukaryote cell signaling. In the present study, by using a knockin approach, we demonstrated the expression and localization of CaM in all...
6.
Gabriel H, Silva M, Kimura E, Wunderlich G, Katzin A, Azevedo M
Antimicrob Agents Chemother
. 2015 Mar;
59(6):3180-8.
PMID: 25779575
The increasing resistance of malaria parasites to almost all available drugs calls for the characterization of novel targets and the identification of new compounds. Carotenoids are polyisoprenoids from plants, algae,...
7.
Howard B, Harvey K, Stewart R, Azevedo M, Crabb B, Jennings I, et al.
ACS Chem Biol
. 2015 Jan;
10(4):1145-54.
PMID: 25555060
Apicomplexan parasites, including Plasmodium falciparum and Toxoplasma gondii, the causative agents of severe malaria and toxoplasmosis, respectively, undergo several critical developmental transitions during their lifecycle. Most important for human pathogenesis...
8.
Koyama F, Azevedo M, Budu A, Chakrabarti D, Garcia C
Int J Mol Sci
. 2014 Dec;
15(12):22320-30.
PMID: 25479077
There is an increasing understanding that melatonin and the ubiquitin/ proteasome system (UPS) interact to regulate multiple cellular functions. Post-translational modifications such as ubiquitination are important modulators of signaling processes,...
9.
Azevedo M, Nie C, Elsworth B, Charnaud S, Sanders P, Crabb B, et al.
PLoS One
. 2014 Nov;
9(11):e112571.
PMID: 25392998
Drug discovery is a key part of malaria control and eradication strategies, and could benefit from sensitive and affordable assays to quantify parasite growth and to help identify the targets...
10.
Elsworth B, Matthews K, Nie C, Kalanon M, Charnaud S, Sanders P, et al.
Nature
. 2014 Jul;
511(7511):587-91.
PMID: 25043043
During the blood stages of malaria, several hundred parasite-encoded proteins are exported beyond the double-membrane barrier that separates the parasite from the host cell cytosol. These proteins have a variety...