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Mauro Delorenzi

Explore the profile of Mauro Delorenzi including associated specialties, affiliations and a list of published articles. Areas
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Articles 172
Citations 18538
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Recent Articles
11.
Heino S, Fang S, Lahde M, Hogstrom J, Nassiri S, Campbell A, et al.
Sci Adv . 2021 Nov; 7(47):eabj0512. PMID: 34788095
Somatic mutations in or genes lead to aberrant Wnt signaling and colorectal cancer (CRC) initiation and progression via-catenin–T cell factor/lymphoid enhancer binding factor TCF/LEF transcription factors. We found that was...
12.
Charmoy M, Wyss T, Delorenzi M, Held W
Cell Rep . 2021 Nov; 37(6):110010. PMID: 34758296
No abstract available.
13.
Duraiswamy J, Turrini R, Minasyan A, Barras D, Crespo I, Grimm A, et al.
Cancer Cell . 2021 Nov; 39(12):1623-1642.e20. PMID: 34739845
The mechanisms regulating exhaustion of tumor-infiltrating lymphocytes (TIL) and responsiveness to PD-1 blockade remain partly unknown. In human ovarian cancer, we show that tumor-specific CD8 TIL accumulate in tumor islets,...
14.
Stalin J, Imhof B, Coquoz O, Jeitziner R, Hammel P, McKee T, et al.
Cancers (Basel) . 2021 Sep; 13(18). PMID: 34572851
The role of the proangiogenic factor olfactomedin-like 3 (OLFML3) in cancer is unclear. To characterize OLFML3 expression in human cancer and its role during tumor development, we undertook tissue expression...
15.
Charmoy M, Wyss T, Delorenzi M, Held W
Cell Rep . 2021 Sep; 36(10):109672. PMID: 34496259
Virus-specific PD1 Tcf1 memory-like CD8 T cells (Ts) maintain the CD8 T cell response during chronic viral infection. However, the fate of these cells following cessation of persistent antigen exposure...
16.
Schaffenrath J, Huang S, Wyss T, Delorenzi M, Keller A
Fluids Barriers CNS . 2021 Jul; 18(1):34. PMID: 34321020
Background: Genetic variation in a population has an influence on the manifestation of monogenic as well as multifactorial disorders, with the underlying genetic contribution dependent on several interacting variants. Common...
17.
Bruand M, Barras D, Mina M, Ghisoni E, Morotti M, Lanitis E, et al.
Cell Rep . 2021 Jul; 36(3):109412. PMID: 34289354
In this study, we investigate mechanisms leading to inflammation and immunoreactivity in ovarian tumors with homologous recombination deficiency (HRD). BRCA1 loss is found to lead to transcriptional reprogramming in tumor...
18.
Gonzalez-Loyola A, Bovay E, Kim J, Lozano T, Sabine A, Renevey F, et al.
Sci Adv . 2021 Jul; 7(29). PMID: 34272244
The mechanisms maintaining adult lymphatic vascular specialization throughout life and their role in coordinating inter-organ communication to sustain homeostasis remain elusive. We report that inactivation of the mechanosensitive transcription factor...
19.
Bibert S, Guex N, Lourenco J, Brahier T, Papadimitriou-Olivgeris M, Damonti L, et al.
Front Immunol . 2021 Jun; 12:666163. PMID: 34135895
The reason why most individuals with COVID-19 have relatively limited symptoms while other develop respiratory distress with life-threatening complications remains unknown. Increasing evidence suggests that COVID-19 associated adverse outcomes mainly...
20.
Gusyatiner O, Bady P, Pham M, Lei Y, Park J, Daniel R, et al.
Neuro Oncol . 2021 May; 23(10):1680-1692. PMID: 33987681
Background: The development of rational combination therapies is key to overcome inherent treatment resistance of glioblastoma (GBM). We aim at identifying new druggable targets by disturbing GBM cells with inhibitors...