Matthieu P M H Benoit
Overview
Explore the profile of Matthieu P M H Benoit including associated specialties, affiliations and a list of published articles.
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13
Citations
101
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Recent Articles
1.
Benoit M, Rao L, Asenjo A, Gennerich A, Sosa H
Nat Commun
. 2024 Jul;
15(1):5530.
PMID: 38956021
Mutations in the microtubule-associated motor protein KIF1A lead to severe neurological conditions known as KIF1A-associated neurological disorders (KAND). Despite insights into its molecular mechanism, high-resolution structures of KIF1A-microtubule complexes remain...
2.
Ranaivoson F, Crozet V, Benoit M, Abdalla Mohammed Khalid A, Kikuti C, Sirkia H, et al.
Open Biol
. 2023 Sep;
13(9):230122.
PMID: 37726093
KIF20A is a critical kinesin for cell division and a promising anti-cancer drug target. The mechanisms underlying its cellular roles remain elusive. Interestingly, unusual coupling between the nucleotide- and microtubule-binding...
3.
Benoit M, Hunter B, Allingham J, Sosa H
Biochem Soc Trans
. 2023 Aug;
51(4):1505-1520.
PMID: 37560910
Kinesin motor proteins couple mechanical movements in their motor domain to the binding and hydrolysis of ATP in their nucleotide-binding pocket. Forces produced through this 'mechanochemical' coupling are typically used...
4.
Benoit M, Rao L, Asenjo A, Gennerich A, Sosa H
bioRxiv
. 2023 Feb;
PMID: 36778368
Mutations in the microtubule-associated motor protein KIF1A lead to severe neurological conditions known as KIF1A-associated neurological disorders (KAND). Despite insights into its molecular mechanism, high-resolution structures of KIF1A-microtubule complexes remain...
5.
Hunter B, Benoit M, Asenjo A, Doubleday C, Trofimova D, Frazer C, et al.
Nat Commun
. 2022 Jul;
13(1):4198.
PMID: 35859148
Kinesin-8s are dual-activity motor proteins that can move processively on microtubules and depolymerize microtubule plus-ends, but their mechanism of combining these distinct activities remains unclear. We addressed this by obtaining...
6.
Benoit M, Asenjo A, Paydar M, Dhakal S, Kwok B, Sosa H
Nat Commun
. 2021 Jun;
12(1):3637.
PMID: 34131133
KIF14 is a mitotic kinesin whose malfunction is associated with cerebral and renal developmental defects and several cancers. Like other kinesins, KIF14 couples ATP hydrolysis and microtubule binding to the...
7.
Benoit M, Asenjo A, Sosa H
Nat Commun
. 2018 Jul;
9(1):2748.
PMID: 29992962
The previously published version of this Article contained an error in Fig. 5. In panels f and g, the α and β symbols were swapped. The error has been corrected...
8.
Benoit M, Asenjo A, Sosa H
Nat Commun
. 2018 Apr;
9(1):1662.
PMID: 29695795
Kinesin-13s constitute a distinct group within the kinesin superfamily of motor proteins that promote microtubule depolymerization and lack motile activity. The molecular mechanism by which kinesin-13s depolymerize microtubules and are...
9.
Benoit M, Sosa H
Methods Mol Biol
. 2017 Sep;
1665:199-216.
PMID: 28940071
Single molecule fluorescence polarization microscopy (smFPM) is a technique that enables to monitor changes in the orientation of a single labeled protein domain. Here we describe a smFPM microscope set-up...
10.
Chatterjee C, Benoit M, DePaoli V, Diaz-Valencia J, Asenjo A, Gerfen G, et al.
Biophys J
. 2016 Apr;
110(7):1593-1604.
PMID: 27074684
Kinesins-13s are members of the kinesin superfamily of motor proteins that depolymerize microtubules (MTs) and have no motile activity. Instead of generating unidirectional movement over the MT lattice, like most...