David J Sharp
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Explore the profile of David J Sharp including associated specialties, affiliations and a list of published articles.
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215
Citations
9407
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Recent Articles
1.
Smith A, Nagrabski S, Baker L, Kramer A, Sharp D, Byrnes K
J Neuroinflammation
. 2025 Mar;
22(1):73.
PMID: 40065364
Spinal cord injury (SCI) can cause permanent dysfunction proceeding from multifaceted neuroinflammatory processes that contribute to damage and repair. Fidgetin-like 2 (FL2), a microtubule-severing enzyme that negatively regulates axon growth,...
2.
Hadi Z, Mahmud M, Calzolari E, Chepisheva M, Zimmerman K, Tahtis V, et al.
J Neurol
. 2025 Jan;
272(2):132.
PMID: 39812836
Background: Vestibular dysfunction causing imbalance affects c. 80% of acute hospitalized traumatic brain injury (TBI) cases. Poor balance recovery is linked to worse return-to-work rates and reduced longevity. We previously...
3.
May H, Tsikonofilos K, Donat C, Sastre M, Kozlov A, Sharp D, et al.
Brain Commun
. 2024 Nov;
6(6):fcae385.
PMID: 39605970
Traumatic brain injury represents a significant global health burden and has the highest prevalence among neurological disorders. Even mild traumatic brain injury can induce subtle, long-lasting changes that increase the...
4.
Mallas E, De Simoni S, Jenkins P, David M, Bourke N, Sharp D
Brain
. 2024 Oct;
PMID: 39432756
Traumatic brain injury commonly impairs attention and executive function, and disrupts the large-scale brain networks that support these cognitive functions. Abnormalities of functional connectivity are seen in corticostriatal networks, which...
5.
Graham N, Blissitt G, Zimmerman K, Orton L, Friedland D, Coady E, et al.
J Neurol Neurosurg Psychiatry
. 2024 Oct;
96(2):105-113.
PMID: 39393903
Background: Traumatic brain injury (TBI) is common in military campaigns and is a risk factor for dementia. rme Serices Truma and Rehabilitatio Outom-TBI (ADVANCE-TBI) aims to ascertain neurological outcomes in...
6.
Parkinson M, Smith R, Tanious K, Curtis F, Doherty R, Colon L, et al.
BMC Geriatr
. 2024 Sep;
24(1):796.
PMID: 39350122
Background: Home monitoring systems utilising artificial intelligence hold promise for digitally enhanced healthcare in older adults. Their real-world use will depend on acceptability to the end user i.e. older adults...
7.
Li L, Kodosaki E, Heslegrave A, Zetterberg H, Graham N, Zimmerman K, et al.
Brain
. 2024 Sep;
148(3):1015-1030.
PMID: 39323289
Pathophysiology and outcomes after traumatic brain injury (TBI) are complex and heterogeneous. Current classifications are uninformative about pathophysiology. Proteomic approaches with fluid-based biomarkers are ideal for exploring complex disease mechanisms,...
8.
Li Y, Luo L, Senicar L, Asrosa R, Kizilates B, Xing K, et al.
Adv Healthc Mater
. 2024 Sep;
13(30):e2401966.
PMID: 39221506
Accurate assessment of neurological disease through monitoring of biomarkers has been made possible using the antibody-based assays. But these assays suffer from expensive development of antibody probes, reliance on complicated...
9.
Smith A, Gregor A, Baker L, Sharp D, Byrnes K
Mol Neurobiol
. 2024 Aug;
62(3):2726-2739.
PMID: 39160390
The microtubule cytoskeleton regulates microglial morphology, motility, and effector functions. The microtubule-severing enzyme, fidgetin-like 2 (FL2), negatively regulates cell motility and nerve regeneration, making it a promising therapeutic target for...
10.
Markerless Motion Capture to Quantify Functional Performance in Neurodegeneration: Systematic Review
Jeyasingh-Jacob J, Crook-Rumsey M, Shah H, Joseph T, Abulikemu S, Daniels S, et al.
JMIR Aging
. 2024 Aug;
7:e52582.
PMID: 39106477
Background: Markerless motion capture (MMC) uses video cameras or depth sensors for full body tracking and presents a promising approach for objectively and unobtrusively monitoring functional performance within community settings,...