Matthias Zebisch
Overview
Explore the profile of Matthias Zebisch including associated specialties, affiliations and a list of published articles.
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30
Citations
1264
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Recent Articles
1.
Logan K, Kaplan W, Simov V, Zhou H, Li D, Torres L, et al.
J Med Chem
. 2024 Sep;
67(18):16807-16819.
PMID: 39231262
Inhibition of leucine-rich repeat kinase 2 is a genetically supported mechanism for the treatment of Parkinson's disease. We previously disclosed the discovery of an indazole series lead that demonstrated both...
2.
Metwally E, Mak V, Soriano A, Zebisch M, Leonardo Silvestre H, McEwan P, et al.
Commun Biol
. 2023 Jul;
6(1):798.
PMID: 37524852
cGMP-dependent protein kinase I-α (PKG1α) is a target for pulmonary arterial hypertension due to its role in the regulation of smooth muscle function. While most work has focused on regulation...
3.
Le K, Soth M, Cross J, Liu G, Ray W, Ma J, et al.
J Med Chem
. 2023 Jul;
66(14):9954-9971.
PMID: 37436942
Chemotherapy-induced peripheral neuropathy (CIPN) is a major unmet medical need with limited treatment options. Despite different mechanisms of action, diverse chemotherapeutics can cause CIPN through a converged pathway─an active axon...
4.
Balibar C, Klein D, Zamlynny B, Diamond T, Fang Z, Cheney C, et al.
Sci Transl Med
. 2023 Feb;
15(684):eabn2038.
PMID: 36812345
Antiretroviral therapy inhibits HIV-1 replication but is not curative due to establishment of a persistent reservoir after virus integration into the host genome. Reservoir reduction is therefore an important HIV-1...
5.
Mak V, Patel A, Yen R, Hanisak J, Lim Y, Bao J, et al.
J Med Chem
. 2022 Jul;
65(15):10318-10340.
PMID: 35878399
Activation of PKG1α is a compelling strategy for the treatment of cardiovascular diseases. As the main effector of cyclic guanosine monophosphate (cGMP), activation of PKG1α induces smooth muscle relaxation in...
6.
Byrne N, Lee A, Kostas J, Reid J, Partridge A, So S, et al.
Protein Expr Purif
. 2020 Nov;
179:105796.
PMID: 33221505
TREM2 has been identified by genomic analysis as a potential and novel target for the treatment of Alzheimer's disease. To enable structure-based screening of potential small molecule therapeutics, we sought...
7.
Dohler C, Zebisch M, Krinke D, Robitzki A, Strater N
Acta Crystallogr F Struct Biol Commun
. 2018 Nov;
74(Pt 11):696-703.
PMID: 30387774
Ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3, ENPP3) is an ATP-hydrolyzing glycoprotein that is located in the extracellular space. The full-length ectodomain of rat NPP3 was expressed in HEK293S GntI cells, purified using two...
8.
Dohler C, Zebisch M, Strater N
Sci Rep
. 2018 Jul;
8(1):10874.
PMID: 30022031
Ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3) is a membrane-bound glycoprotein that regulates extracellular levels of nucleotides. NPP3 is known to contribute to the immune response on basophils by hydrolyzing ATP and to regulate...
9.
Zebisch M, Jackson V, Zhao Y, Jones E
Structure
. 2016 Aug;
24(9):1599-605.
PMID: 27524201
Kremen 1 and 2 have been identified as co-receptors for Dickkopf (Dkk) proteins, hallmark secreted antagonists of canonical Wnt signaling. We present here three crystal structures of the ectodomain of...
10.
Chang T, Hsieh F, Zebisch M, Harlos K, Elegheert J, Jones E
Elife
. 2015 Jul;
4.
PMID: 26158506
Wnt signalling regulates multiple processes including angiogenesis, inflammation, and tumorigenesis. Norrin (Norrie Disease Protein) is a cystine-knot like growth factor. Although unrelated to Wnt, Norrin activates the Wnt/β-catenin pathway. Signal...