Matthias P Wymann
Overview
Explore the profile of Matthias P Wymann including associated specialties, affiliations and a list of published articles.
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78
Citations
3883
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Recent Articles
1.
Bissegger L, Constantin T, Keles E, Raguz L, Barlow-Busch I, Orbegozo C, et al.
Chem Sci
. 2024 Nov;
15(48):20274-20291.
PMID: 39568927
Chemical probes have gained importance in the elucidation of signal transduction in biology. Insufficient selectivity and potency, lack of cellular activity and inappropriate use of chemical probes has major consequences...
2.
Koumantou D, Adiko A, Bourdely P, Nugue M, Boedec E, El-Benna J, et al.
Adv Sci (Weinh)
. 2024 Oct;
11(44):e2401179.
PMID: 39382167
Cross-presentation by MHCI is optimally efficient in type 1 dendritic cells (DC) due to their high capacity for antigen processing. However, through specific pathways, other DCs, such as type 2...
3.
Schaefer T, Mittal N, Wang H, Ataman M, Candido S, Lotscher J, et al.
Cell Rep
. 2024 Oct;
43(10):114807.
PMID: 39368083
Stemness and pluripotency are mediated by transcriptional master regulators that promote self-renewal and repress cell differentiation, among which is the high-mobility group (HMG) box transcription factor SOX2. Dysregulated SOX2 expression,...
4.
Lanahan S, Yang L, Jones K, Qi Z, Cruz Cabrera E, Cominsky L, et al.
Nat Immunol
. 2024 Jul;
25(8):1422-1431.
PMID: 38961274
The differentiation of naive and memory B cells into antibody-secreting cells (ASCs) is a key feature of adaptive immunity. The requirement for phosphoinositide 3-kinase-delta (PI3Kδ) to support B cell biology...
5.
De Pascale M, Bissegger L, Tarantelli C, Beaufils F, Prescimone A, Mohamed Seid Hedad H, et al.
Eur J Med Chem
. 2023 Jan;
248:115038.
PMID: 36634458
Upregulation of mechanistic target of rapamycin (mTOR) signaling drives various types of cancers and neurological diseases. Rapamycin and its analogues (rapalogs) are first generation mTOR inhibitors, and selectively block mTOR...
6.
7.
Borsari C, Keles E, McPhail J, Schaefer A, Sriramaratnam R, Goch W, et al.
J Am Chem Soc
. 2022 Mar;
144(14):6326-6342.
PMID: 35353516
Covalent protein kinase inhibitors exploit currently noncatalytic cysteines in the adenosine 5'-triphosphate (ATP)-binding site via electrophiles directly appended to a reversible-inhibitor scaffold. Here, we delineate a path to target solvent-exposed...
8.
Lanahan S, Wymann M, Lucas C
Nat Rev Immunol
. 2022 Mar;
22(11):687-700.
PMID: 35322259
Over the past two decades, new insights have positioned phosphoinositide 3-kinase-γ (PI3Kγ) as a context-dependent modulator of immunity and inflammation. Recent advances in protein structure determination and drug development have...
9.
Mori M, Ruer-Laventie J, Duchemin W, Demougin P, Ndinyanka Fabrice T, Wymann M, et al.
Sci Signal
. 2021 Dec;
14(714):eabj0057.
PMID: 34932374
The control of T cell survival is crucial for defense against infectious pathogens or emerging cancers. Although the survival of peripheral naïve T cells has been proposed to be controlled...
10.
Borsari C, Wymann M
Chimia (Aarau)
. 2021 Dec;
75(12):1037-1044.
PMID: 34920774
Phosphoinositide 3-kinase (PI3K) plays a key role in a plethora of physiologic processes and controls cell growth, metabolism, immunity, cardiovascular and neurological function, and more. The discovery of wort-mannin as...