Matthias Marczynski
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Explore the profile of Matthias Marczynski including associated specialties, affiliations and a list of published articles.
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9
Citations
93
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Recent Articles
1.
Schlatterer R, Marczynski M, Hermann B, Lieleg O, Balzer B
Nano Lett
. 2025 Jan;
25(5):1765-1774.
PMID: 39841791
Mucins are the macromolecular key components of mucus. On wet epithelia of mammals, mucin solutions and gels act as powerful biolubricants and reduce friction and wear by generating a sacrificial...
2.
Marczynski M, Lieleg O
Biophys Rev (Melville)
. 2024 Mar;
2(3):031302.
PMID: 38505633
A decade ago, environmental issues, such as air pollution and the contamination of the oceans with microplastic, were prominently communicated in the media. However, these days, political topics, as well...
3.
Singanayagam A, Footitt J, Marczynski M, Radicioni G, Cross M, Finney L, et al.
J Clin Invest
. 2022 Mar;
132(8).
PMID: 35239513
The respiratory tract surface is protected from inhaled pathogens by a secreted layer of mucus rich in mucin glycoproteins. Abnormal mucus accumulation is a cardinal feature of chronic respiratory diseases,...
4.
Marczynski M, Kimna C, Lieleg O
Adv Drug Deliv Rev
. 2021 Jun;
178:113845.
PMID: 34166760
One of the main challenges in the field of drug delivery remains the development of strategies to efficiently transport pharmaceuticals across mucus barriers, which regulate the passage and retention of...
5.
Marczynski M, Jiang K, Blakeley M, Srivastava V, Vilaplana F, Crouzier T, et al.
Biomacromolecules
. 2021 Mar;
22(4):1600-1613.
PMID: 33749252
Commercial mucin glycoproteins are routinely used as a model to investigate the broad range of important functions mucins fulfill in our bodies, including lubrication, protection against hostile germs, and the...
6.
Lutz T, Marczynski M, Grill M, Wall W, Lieleg O
Langmuir
. 2020 Oct;
36(43):12973-12982.
PMID: 33090801
Mucin glycoproteins are the matrix-forming key components of mucus, the innate protective barrier protecting us from pathogenic attack. However, this barrier is constantly challenged by mucin-degrading enzymes, which tend to...
7.
Rickert C, Lutz T, Marczynski M, Lieleg O
Macromol Biosci
. 2020 May;
20(7):e2000090.
PMID: 32431054
Mucin glycoproteins, the macromolecular components of mucus, combine a broad range of biomedically important properties. Among those is the ability of mucin solutions to act as excellent lubricants. However, to...
8.
Marczynski M, Balzer B, Jiang K, Lutz T, Crouzier T, Lieleg O
Colloids Surf B Biointerfaces
. 2019 Nov;
187:110614.
PMID: 31753616
In the human body, mucin glycoproteins efficiently reduce friction between tissues and thereby protect the mucosa from mechanical damage. Mucin lubricity is closely related to their molecular structure: it has...
9.
Marczynski M, Rickert C, Semerdzhiev S, van Dijk W, Segers-Nolten I, Claessens M, et al.
Biomacromolecules
. 2019 Nov;
20(12):4332-4344.
PMID: 31721560
Recent research indicates that the progression of Parkinson's disease can start from neurons of the enteric nervous system, which are in close contact with the gastrointestinal epithelium: α-synuclein molecules can...
10.
Marczynski M, Kasdorf B, Altaner B, Wenzler A, Gerland U, Lieleg O
Biomater Sci
. 2018 Oct;
6(12):3373-3387.
PMID: 30362469
Here, we present a microfluidics chip platform which allows for studying the charge-dependent transport of molecules across the interface of acidic mucin gels. With this setup, we demonstrate a selective...