Matthias Kuhnle
Overview
Explore the profile of Matthias Kuhnle including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
104
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Recent Articles
1.
BK K+ channel blockade inhibits radiation-induced migration/brain infiltration of glioblastoma cells
Edalat L, Stegen B, Klumpp L, Haehl E, Schilbach K, Lukowski R, et al.
Oncotarget
. 2016 Feb;
7(12):14259-78.
PMID: 26893360
Infiltration of the brain by glioblastoma cells reportedly requires Ca2+ signals and BK K+ channels that program and drive glioblastoma cell migration, respectively. Ionizing radiation (IR) has been shown to...
2.
Ochoa-Puentes C, Bauer S, Kuhnle M, Bernhardt G, Buschauer A, Konig B
ACS Med Chem Lett
. 2014 Jun;
4(4):393-6.
PMID: 24900683
Recently reported compounds such as UR-COP78 (6) are among the most potent and selective ABCG2 modulators known so far but are prone to rapid enzymatic cleavage at the central benzanilide...
3.
Puentes C, Hocherl P, Kuhnle M, Bauer S, Burger K, Bernhardt G, et al.
Bioorg Med Chem Lett
. 2011 May;
21(12):3654-7.
PMID: 21570282
Aiming at structural optimization of potent and selective ABCG2 inhibitors, such as UR-ME22-1, from our laboratory, an efficient solid phase synthesis was developed to get convenient access to this class...
4.
Kuhnle M, Egger M, Muller C, Mahringer A, Bernhardt G, Fricker G, et al.
J Med Chem
. 2009 Jan;
52(4):1190-7.
PMID: 19170519
The efflux pumps ABCB1 (p-gp, MDR1) and ABCG2 (BCRP) are expressed to a high extent by endothelial cells at the blood-brain barrier (BBB) and other barrier tissues and are involved...