Matthias D Erlacher
Overview
Explore the profile of Matthias D Erlacher including associated specialties, affiliations and a list of published articles.
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13
Citations
187
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Recent Articles
1.
Krasheninina O, Thaler J, Erlacher M, Micura R
Angew Chem Weinheim Bergstr Ger
. 2024 Mar;
133(13):7046-7050.
PMID: 38504956
A major challenge in the field of RNA chemistry is the identification of selective and quantitative conversion reactions on RNA that can be used for tagging and any other RNA...
2.
Kompatscher M, Bartosik K, Erharter K, Plangger R, Juen F, Kreutz C, et al.
Nucleic Acids Res
. 2023 Dec;
52(3):1374-1386.
PMID: 38050960
tRNA superwobbling, used by certain bacteria and organelles, is an intriguing decoding concept in which a single tRNA isoacceptor is used to decode all synonymous codons of a four-fold degenerate...
3.
Kohl M, Kompatscher M, Clementi N, Holl L, Erlacher M
Nucleic Acids Res
. 2022 Dec;
51(1):271-289.
PMID: 36546769
During initiation, the ribosome is tasked to efficiently recognize open reading frames (ORFs) for accurate and fast translation of mRNAs. A critical step is start codon recognition, which is modulated...
4.
Krasheninina O, Thaler J, Erlacher M, Micura R
Angew Chem Int Ed Engl
. 2021 Jan;
60(13):6970-6974.
PMID: 33400347
A major challenge in the field of RNA chemistry is the identification of selective and quantitative conversion reactions on RNA that can be used for tagging and any other RNA...
5.
Hoernes T, Erlacher M
Methods Mol Biol
. 2017 Mar;
1562:283-294.
PMID: 28349468
Methylated RNA nucleotides were recently discovered to be highly abundant in RNAs. The effects of these methylations were mainly attributed to altered mRNA stabilities, protein-binding affinities, or RNA structures. The...
6.
Erlacher M, Polacek N
Methods Mol Biol
. 2012 Feb;
848:215-26.
PMID: 22315072
The ribosome is a huge ribonucleoprotein complex in charge of protein synthesis in every living cell. The catalytic center of this dynamic molecular machine is entirely built up of 23S...
7.
Generation of chemically engineered ribosomes for atomic mutagenesis studies on protein biosynthesis
Erlacher M, Chirkova A, Voegele P, Polacek N
Nat Protoc
. 2011 Apr;
6(5):580-92.
PMID: 21527916
The protocol describes the site-specific chemical modification of 23S rRNA of Thermus aquaticus ribosomes. The centerpiece of this 'atomic mutagenesis' approach is the site-specific incorporation of non-natural nucleoside analogs into...
8.
Chirkova A, Erlacher M, Clementi N, Zywicki M, Aigner M, Polacek N
Nucleic Acids Res
. 2010 Apr;
38(14):4844-55.
PMID: 20375101
Despite the fact that all 23S rRNA nucleotides that build the ribosomal peptidyl transferase ribozyme are universally conserved, standard and atomic mutagenesis studies revealed the nucleobase identities being non-critical for...
9.
Wieland M, Berschneider B, Erlacher M, Hartig J
Chem Biol
. 2010 Mar;
17(3):236-42.
PMID: 20338515
Developing artificial genetic switches in order to control gene expression via an external stimulus is an important aim in chemical and synthetic biology. Here, we expand the application range of...
10.
Erlacher M, Polacek N
RNA Biol
. 2008 Apr;
5(1):5-12.
PMID: 18388484
Over time the mechanistic concepts to describe the two principal chemical reactions that are catalyzed by the ribosome, peptide bond formation and peptidyl-tRNA hydrolysis, have undergone dramatic changes. While the...