Matthew Traylor
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Explore the profile of Matthew Traylor including associated specialties, affiliations and a list of published articles.
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94
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6022
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Recent Articles
1.
Keaton J, Kamali Z, Xie T, Vaez A, Williams A, Goleva S, et al.
Nat Genet
. 2024 Apr;
56(5):778-791.
PMID: 38689001
Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P < 5 × 10) from the largest...
2.
Liu J, Hu S, Chen L, Daly C, Prada Medina C, Richardson T, et al.
medRxiv
. 2023 Dec;
PMID: 38076879
Background & Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) affects over 25% of the population and currently has no effective treatments. Plasma proteins with causal evidence may represent promising drug...
3.
Sun B, Chiou J, Traylor M, Benner C, Hsu Y, Richardson T, et al.
Nature
. 2023 Oct;
622(7982):329-338.
PMID: 37794186
The Pharma Proteomics Project is a precompetitive biopharmaceutical consortium characterizing the plasma proteomic profiles of 54,219 UK Biobank participants. Here we provide a detailed summary of this initiative, including technical...
4.
Ishigaki K, Sakaue S, Terao C, Luo Y, Sonehara K, Yamaguchi K, et al.
Nat Genet
. 2022 Nov;
54(11):1640-1651.
PMID: 36333501
Rheumatoid arthritis (RA) is a highly heritable complex disease with unknown etiology. Multi-ancestry genetic research of RA promises to improve power to detect genetic signals, fine-mapping resolution and performances of...
5.
Chen L, Peters J, Prins B, Persyn E, Traylor M, Surendran P, et al.
Nat Commun
. 2022 Oct;
13(1):6143.
PMID: 36253349
Stroke is the second leading cause of death with substantial unmet therapeutic needs. To identify potential stroke therapeutic targets, we estimate the causal effects of 308 plasma proteins on stroke...
6.
Ryan D, Karhunen V, Su B, Traylor M, Richardson T, Burgess S, et al.
Neurol Genet
. 2022 Sep;
8(5):e200014.
PMID: 36046424
Background And Objectives: Angiotensin-converting enzyme (ACE) inhibitors are a commonly prescribed class of medication used to treat heart failure, hypertension, and chronic kidney disease. However, previous observational studies have shown...
7.
Granata A, Kasioulis I, Serrano F, Cooper J, Traylor M, Sinha S, et al.
Front Cardiovasc Med
. 2022 Apr;
9:849664.
PMID: 35433850
A common variant in the Histone Deacetylase 9 () gene is the strongest genetic risk for large-vessel stroke, and HDAC9 offers a novel target for therapeutic modulation. However, the mechanisms...
8.
Taylor-Bateman V, Gill D, Georgakis M, Malik R, Munroe P, Traylor M
Neurology
. 2021 Nov;
98(4):e343-e351.
PMID: 34845052
Background And Objectives: Cardiovascular risk factors have been implicated in the etiology of cerebral small vessel disease (CSVD); however, whether the associations are causal remains unclear in part due to...
9.
Hanscombe K, Persyn E, Traylor M, Glanville K, Hamer M, Coleman J, et al.
Genome Med
. 2021 Nov;
13(1):180.
PMID: 34753499
Background: Cardiorespiratory fitness (CRF) and physical activity (PA) are well-established predictors of morbidity and all-cause mortality. However, CRF is not routinely measured and PA not routinely prescribed as part of...
10.
Malik R, Beaufort N, Frerich S, Gesierich B, Georgakis M, Rannikmae K, et al.
Brain
. 2021 Oct;
144(9):2670-2682.
PMID: 34626176
White matter hyperintensities (WMH) are among the most common radiological abnormalities in the ageing population and an established risk factor for stroke and dementia. While common variant association studies have...