Matthew T Greenfield
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Explore the profile of Matthew T Greenfield including associated specialties, affiliations and a list of published articles.
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16
Citations
479
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Recent Articles
1.
Huang W, Li F, Gong Y, Zhang Y, Youngsaye W, Xu Y, et al.
Bioorg Med Chem Lett
. 2022 Nov;
80:129084.
PMID: 36423823
In the treatment of non-small cell lung cancer (NSCLC), patients harboring exon 20 insertion mutations in the epidermal growth factor receptor (EGFR) gene (EGFR) have few effective therapies because this...
2.
Gonzalvez F, Vincent S, Baker T, Gould A, Li S, Wardwell S, et al.
Cancer Discov
. 2021 Feb;
11(7):1672-1687.
PMID: 33632773
Most exon 20 insertion (ex20ins) driver mutations in non-small cell lung cancer (NSCLC) are insensitive to approved EGFR tyrosine kinase inhibitors (TKI). To address the limitations of existing therapies targeting...
3.
Nivorozhkin A, Kolodziej A, Caravan P, Greenfield M, Lauffer R, McMurry T
Angew Chem Int Ed Engl
. 2018 May;
40(15):2903-2906.
PMID: 29711998
Clinically relevant relaxivity enhancement of a magnetic resonance imaging (MRI) contrast agent has been achieved by using prodrug Gd complexes (see picture, DTPA=diethylenetriaminepentaaceto). Enzymatic cleavage of lysine residues from the...
4.
Zech S, Kohlmann A, Zhou T, Li F, Squillace R, Parillon L, et al.
J Med Chem
. 2015 Dec;
59(2):671-86.
PMID: 26700752
Choline kinase α (ChoKα) is an enzyme involved in the synthesis of phospholipids and thereby plays key roles in regulation of cell proliferation, oncogenic transformation, and human carcinogenesis. Since several...
5.
Kohlmann A, Zech S, Li F, Zhou T, Squillace R, Commodore L, et al.
J Med Chem
. 2013 Jan;
56(3):1023-40.
PMID: 23302067
Lactate dehydrogenase A (LDH-A) catalyzes the interconversion of lactate and pyruvate in the glycolysis pathway. Cancer cells rely heavily on glycolysis instead of oxidative phosphorylation to generate ATP, a phenomenon...
6.
Zhang Z, Kolodziej A, Greenfield M, Caravan P
Angew Chem Int Ed Engl
. 2011 Mar;
50(11):2621-4.
PMID: 21370351
No abstract available.
7.
Jacques V, Dumas S, Sun W, Troughton J, Greenfield M, Caravan P
Invest Radiol
. 2010 Sep;
45(10):613-24.
PMID: 20808234
Rationale And Objectives: The observed relaxivity of gadolinium-based contrast agents has contributions from the water molecule(s) that bind directly to the gadolinium ion (inner-sphere water), long-lived water molecules and exchangeable...
8.
Zhang Z, Kolodziej A, Qi J, Nair S, Wang X, Case A, et al.
New J Chem
. 2010 Jun;
2010(34):611-616.
PMID: 20526382
A strategy for preparing high relaxivity, metabolically stable peptide-based MR contrast agents is described.
9.
Spuentrup E, Ruhl K, Botnar R, Wiethoff A, Buhl A, Jacques V, et al.
Circulation
. 2009 Mar;
119(13):1768-75.
PMID: 19307474
Background: Cardiac magnetic resonance (MR) perfusion imaging during the first pass after intravenous administration of extracellular contrast agents is hampered by the spatial and temporal resolution achievable and by the...
10.
Woods M, Caravan P, Geraldes C, Greenfield M, Kiefer G, Lin M, et al.
Invest Radiol
. 2008 Nov;
43(12):861-70.
PMID: 19002058
Objectives: Recent advances in the design of MRI contrast agents have rendered the lanthanide complexes of DOTA-tetraamide ligands of considerable interest, both as responsive MR agents and paramagnetic chemical exchange...