Matthew S Sachs
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Explore the profile of Matthew S Sachs including associated specialties, affiliations and a list of published articles.
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3820
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Recent Articles
1.
Loughran G, Andreev D, Terenin I, Namy O, Mikl M, Yordanova M, et al.
Nat Struct Mol Biol
. 2025 Mar;
PMID: 40033152
Dual reporters encoding two distinct proteins within the same mRNA have had a crucial role in identifying and characterizing unconventional mechanisms of eukaryotic translation. These mechanisms include initiation via internal...
2.
Bian Z, Xu Z, Peer A, Choi Y, Priest S, Akritidou K, et al.
mBio
. 2025 Feb;
:e0022325.
PMID: 39998264
Fungal sexual reproduction is controlled by the mating-type () locus. In contrast to a majority of species in the phylum Basidiomycota that have tetrapolar mating-type systems, the opportunistic human pathogen...
3.
Bian Z, Xu Z, Peer A, Choi Y, Priest S, Akritidou K, et al.
bioRxiv
. 2024 Dec;
PMID: 39677606
Fungal sexual reproduction is controlled by the mating-type () locus. In contrast to a majority of species in the phylum Basidiomycota that have tetrapolar mating-type systems, the opportunistic human pathogen...
4.
Stukey G, Breuer M, Burchat N, Jog R, Schultz K, Han G, et al.
J Lipid Res
. 2024 Nov;
66(1):100711.
PMID: 39577771
Phosphatidic acid phosphatase (PAP) is an evolutionarily conserved eukaryotic enzyme that catalyzes the Mg-dependent dephosphorylation of phosphatidic acid to produce diacylglycerol. The product and substrate of PAP are key intermediates...
5.
Functional domains of a ribosome arresting peptide are affected by surrounding nonconserved residues
Judd H, Martinez A, Klepacki D, Vazquez-Laslop N, Sachs M, Cruz-Vera L
J Biol Chem
. 2024 Feb;
300(3):105780.
PMID: 38395310
Expression of the Escherichia coli tnaCAB operon, responsible for L-tryptophan (L-Trp) transport and catabolism, is regulated by L-Trp-directed translation arrest and the ribosome arresting peptide TnaC. The function of TnaC...
6.
Galvao-Rocha F, Rocha C, Martins M, Sanches P, Bitencourt T, Sachs M, et al.
J Fungi (Basel)
. 2023 Feb;
9(2).
PMID: 36836389
The dermatophyte is responsible for most human cutaneous infections. Its treatment is complex, mainly because there are only a few structural classes of fungal inhibitors. Therefore, new strategies addressing these...
7.
Castillo K, Wu C, Ding Z, Lopez-Garcia O, Rowlinson E, Sachs M, et al.
Cell Rep
. 2022 Dec;
41(13):111879.
PMID: 36577368
Phosphorylation of Neurospora crassa eukaryotic initiation factor 2 α (eIF2α), a conserved translation initiation factor, is clock controlled. To determine the impact of rhythmic eIF2α phosphorylation on translation, we performed...
8.
Breuer M, Dasgupta A, Vasselli J, Lin X, Shaw B, Sachs M
J Fungi (Basel)
. 2022 Jun;
8(6).
PMID: 35736125
The prevalence and increasing incidence of fungal infections globally is a significant worldwide health problem. Cryptococcosis, primarily caused by the pathogenic yeast , is responsible for approximately 181,000 estimated deaths...
9.
Zgadzay Y, Kolosova O, Stetsenko A, Wu C, Bruchlen D, Usachev K, et al.
Sci Adv
. 2022 May;
8(21):eabn1062.
PMID: 35613268
is a widespread commensal fungus with substantial pathogenic potential and steadily increasing resistance to current antifungal drugs. It is known to be resistant to cycloheximide (CHX) that binds to the...
10.
Shen L, Su Z, Yang K, Wu C, Becker T, Bell-Pedersen D, et al.
Proc Natl Acad Sci U S A
. 2021 Nov;
118(48).
PMID: 34815343
Ribosomes translate RNA into proteins. The protein synthesis inhibitor cycloheximide (CHX) is widely used to inhibit eukaryotic ribosomes engaged in translation elongation. However, the lack of structural data for actively...