Matthew S Gill
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Explore the profile of Matthew S Gill including associated specialties, affiliations and a list of published articles.
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25
Citations
503
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Recent Articles
1.
Kim J, Buffenstein R, Bronikowski A, Pilar Vanegas N, Rosas L, Agudelo-Garcia P, et al.
J Gerontol A Biol Sci Med Sci
. 2024 Nov;
79(11).
PMID: 39498863
The Midwest Aging Consortium (MAC) has emerged as a critical collaborative initiative aimed at advancing our understanding of aging and developing strategies to combat the rising prevalence of age-related diseases....
2.
Martinez B, Gill M
PLoS One
. 2023 Jul;
18(7):e0288764.
PMID: 37471418
We have previously characterized a truncated isoform of the C. elegans insulin-like receptor, DAF-2B, which retains the ligand binding domain but cannot transduce a signal due to the absence of...
3.
Martinez B, Gill M
G3 (Bethesda)
. 2023 Mar;
13(6).
PMID: 36966398
The alternatively spliced daf-2b transcript in Caenorhabditis elegans encodes a truncated isoform of the nematode insulin receptor that retains the extracellular ligand binding domain but lacks the intracellular signaling domain...
4.
Martinez B, Rodrigues P, Nunez Medina R, Mondal P, Harrison N, Lone M, et al.
Elife
. 2020 Feb;
9.
PMID: 32096469
In the nematode , insulin signaling regulates development and aging in response to the secretion of numerous insulin peptides. Here, we describe a novel, non-signaling isoform of the nematode insulin...
5.
Wang D, Stoveken H, Zucca S, Dao M, Orlandi C, Song C, et al.
Science
. 2019 Aug;
365(6459):1267-1273.
PMID: 31416932
Opioids target the μ-opioid receptor (MOR) to produce unrivaled pain management, but their addictive properties can lead to severe abuse. We developed a whole-animal behavioral platform for unbiased discovery of...
6.
Gurkar A, Robinson A, Cui Y, Li X, Allani S, Webster A, et al.
Redox Biol
. 2018 Jul;
18:191-199.
PMID: 30031267
DNA damage is presumed to be one type of stochastic macromolecular damage that contributes to aging, yet little is known about the precise mechanism by which DNA damage drives aging....
7.
Lucanic M, Garrett T, Gill M, Lithgow G
J Vis Exp
. 2018 Apr;
(133).
PMID: 29630057
Caenorhabditis elegans is a useful organism for testing chemical effects on physiology. Whole organism small molecule screens offer significant advantages for identifying biologically active chemical structures that can modify complex...
8.
Burd C, Gill M, Niedernhofer L, Robbins P, Austad S, Barzilai N, et al.
J Gerontol A Biol Sci Med Sci
. 2016 Aug;
71(11):1388-1394.
PMID: 27535964
Through the progress of basic science research, fundamental mechanisms that contribute to age-related decline are being described with increasing depth and detail. Although these efforts have identified new drug targets...
9.
Lucanic M, Garrett T, Yu I, Calahorro F, Shahmirzadi A, Miller A, et al.
Aging Cell
. 2016 May;
15(5):832-41.
PMID: 27220516
Model organisms subject to dietary restriction (DR) generally live longer. Accompanying this lifespan extension are improvements in overall health, based on multiple metrics. This indicates that pharmacological treatments that mimic...
10.
Rodrigues P, Kaul T, Ho J, Lucanic M, Burkewitz K, Mair W, et al.
G3 (Bethesda)
. 2016 May;
6(6):1695-705.
PMID: 27172180
Under adverse environmental conditions the nematode Caenorhabditis elegans can enter an alternate developmental stage called the dauer larva. To identify lipophilic signaling molecules that influence this process, we screened a...