Matthew R Huska
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Explore the profile of Matthew R Huska including associated specialties, affiliations and a list of published articles.
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15
Citations
703
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Recent Articles
1.
Watkins T, Colliver E, Huska M, Kaufmann T, Lim E, Duncan C, et al.
PLoS Comput Biol
. 2023 Oct;
19(10):e1011379.
PMID: 37871126
Most computational methods that infer somatic copy number alterations (SCNAs) from bulk sequencing of DNA analyse tumour samples individually. However, the sequencing of multiple tumour samples from a patient's disease...
2.
Calabrese C, Davidson N, Demircioglu D, Fonseca N, He Y, Kahles A, et al.
Nature
. 2023 Jan;
614(7948):E37.
PMID: 36697831
No abstract available.
3.
Andrade-Navarro M, Muhlenberg K, Spruth E, Mah N, Gonzalez-Lopez A, Andreani T, et al.
Front Neurol
. 2020 Dec;
11:573560.
PMID: 33329316
Huntington's disease (HD) is an autosomal dominantly inherited neurodegenerative disorder caused by a trinucleotide repeat expansion in the gene. As disease-modifying therapies for HD are being developed, peripheral blood cells...
4.
Calabrese C, Davidson N, Demircioglu D, Fonseca N, He Y, Kahles A, et al.
Nature
. 2020 Feb;
578(7793):129-136.
PMID: 32025019
Transcript alterations often result from somatic changes in cancer genomes. Various forms of RNA alterations have been described in cancer, including overexpression, altered splicing and gene fusions; however, it is...
5.
Boeddrich A, Babila J, Wiglenda T, Diez L, Jacob M, Nietfeld W, et al.
Cell Chem Biol
. 2018 Nov;
26(1):109-120.e7.
PMID: 30472115
Self-propagating amyloid-β (Aβ) aggregates or seeds possibly drive pathogenesis of Alzheimer's disease (AD). Small molecules targeting such structures might act therapeutically in vivo. Here, a fluorescence polarization assay was established...
6.
Love M, Huska M, Jurk M, Schopflin R, Starick S, Schwahn K, et al.
Nucleic Acids Res
. 2016 Dec;
45(4):1805-1819.
PMID: 27903902
The genomic loci bound by the glucocorticoid receptor (GR), a hormone-activated transcription factor, show little overlap between cell types. To study the role of chromatin and sequence in specifying where...
7.
Concerted down-regulation of immune-system related genes predicts metastasis in colorectal carcinoma
Fehlker M, Huska M, Jons T, Andrade-Navarro M, Kemmner W
BMC Cancer
. 2014 Feb;
14:64.
PMID: 24495478
Background: This study aimed at the identification of prognostic gene expression markers in early primary colorectal carcinomas without metastasis at the time point of surgery by analyzing genome-wide gene expression...
8.
PROmiRNA: a new miRNA promoter recognition method uncovers the complex regulation of intronic miRNAs
Marsico A, Huska M, Lasserre J, Hu H, Vucicevic D, Musahl A, et al.
Genome Biol
. 2013 Aug;
14(8):R84.
PMID: 23958307
The regulation of intragenic miRNAs by their own intronic promoters is one of the open problems of miRNA biogenesis. Here, we describe PROmiRNA, a new approach for miRNA promoter annotation...
9.
Christ A, Terryn S, Schmidt V, Christensen E, Huska M, Andrade-Navarro M, et al.
Kidney Int
. 2010 Jun;
78(5):473-7.
PMID: 20531455
Megalin-mediated endocytic uptake constitutes the main pathway for clearance of plasma proteins from the glomerular filtrate in proximal tubules. Little is known, however, about mechanisms that control megalin expression and...
10.
Broske A, Vockentanz L, Kharazi S, Huska M, Mancini E, Scheller M, et al.
Nat Genet
. 2009 Oct;
41(11):1207-15.
PMID: 19801979
DNA methylation is a dynamic epigenetic mark that undergoes extensive changes during differentiation of self-renewing stem cells. However, whether these changes are the cause or consequence of stem cell fate...