Matthew R Hassler
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Explore the profile of Matthew R Hassler including associated specialties, affiliations and a list of published articles.
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23
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899
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Recent Articles
1.
Yamada K, Hariharan V, Caiazzi J, Miller R, Ferguson C, Sapp E, et al.
Nat Biotechnol
. 2024 Aug;
PMID: 39090305
Therapeutic small interfering RNA (siRNA) requires sugar and backbone modifications to inhibit nuclease degradation. However, metabolic stabilization by phosphorothioate (PS), the only backbone chemistry used clinically, may be insufficient for...
2.
Weiss A, Gilbert J, Rivera Flores I, Belgrad J, Ferguson C, Dogan E, et al.
bioRxiv
. 2024 Jul;
PMID: 38979291
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition, with 20% of familial and 2-3% of sporadic cases linked to mutations in the cytosolic superoxide dismutase (SOD1) gene. Mutant SOD1...
3.
Yamada K, Hariharan V, Caiazzi J, Miller R, Furguson C, Sapp E, et al.
bioRxiv
. 2023 Jun;
PMID: 37292886
Metabolic stabilization of therapeutic oligonucleotides requires both sugar and backbone modifications, where phosphorothioate (PS) is the only backbone chemistry used in the clinic. Here, we describe the discovery, synthesis, and...
4.
Conroy F, Miller R, Alterman J, Hassler M, Echeverria D, Godinho B, et al.
Nat Commun
. 2022 Oct;
13(1):5802.
PMID: 36192390
Small interfering RNAs are a new class of drugs, exhibiting sequence-driven, potent, and sustained silencing of gene expression in vivo. We recently demonstrated that siRNA chemical architectures can be optimized...
5.
Godinho B, Knox E, Hildebrand S, Gilbert J, Echeverria D, Kennedy Z, et al.
Mol Ther Nucleic Acids
. 2022 Jul;
29:116-132.
PMID: 35795486
Effective systemic delivery of small interfering RNAs (siRNAs) to tissues other than liver remains a challenge. siRNAs are small (∼15 kDa) and therefore rapidly cleared by the kidneys, resulting in...
6.
Yamada K, Hildebrand S, Davis S, Miller R, Conroy F, Sapp E, et al.
Nucleic Acids Res
. 2021 Dec;
49(21):12069-12088.
PMID: 34850120
Oligonucleotides is an emerging class of chemically-distinct therapeutic modalities, where extensive chemical modifications are fundamental for their clinical applications. Inter-nucleotide backbones are critical to the behaviour of therapeutic oligonucleotides, but...
7.
Yenilmez B, Wetoska N, Kelly M, Echeverria D, Min K, Lifshitz L, et al.
Mol Ther
. 2021 Nov;
30(3):1329-1342.
PMID: 34774753
Nonalcoholic steatohepatitis (NASH) is a severe liver disorder characterized by triglyceride accumulation, severe inflammation, and fibrosis. With the recent increase in prevalence, NASH is now the leading cause of liver...
8.
Davis S, Sousa J, Vangjeli L, Hassler M, Echeverria D, Knox E, et al.
Mol Ther Nucleic Acids
. 2020 Jul;
21:266-277.
PMID: 32610253
Small interfering RNAs (siRNAs) have the potential to treat a broad range of diseases. siRNAs need to be extensively chemically modified to improve their bioavailability, safety, and stability in vivo....
9.
Alterman J, Godinho B, Hassler M, Ferguson C, Echeverria D, Sapp E, et al.
Nat Biotechnol
. 2019 Aug;
37(8):884-894.
PMID: 31375812
Sustained silencing of gene expression throughout the brain using small interfering RNAs (siRNAs) has not been achieved. Here we describe an siRNA architecture, divalent siRNA (di-siRNA), that supports potent, sustained...
10.
Haraszti R, Miller R, Dubuke M, Rockwell H, Coles A, Sapp E, et al.
iScience
. 2019 Jun;
16:230-241.
PMID: 31195240
Exosomes can serve as delivery vehicles for advanced therapeutics. The components necessary and sufficient to support exosomal delivery have not been established. Here we connect biochemical composition and activity of...