Andrew H Coles
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Explore the profile of Andrew H Coles including associated specialties, affiliations and a list of published articles.
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35
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1445
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Recent Articles
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Ly S, Didiot M, Ferguson C, Coles A, Miller R, Chase K, et al.
Brain Commun
. 2022 Dec;
4(6):fcac248.
PMID: 36458209
Mutant messenger RNA (mRNA) and protein contribute to the clinical manifestation of many repeat-associated neurological disorders, with the presence of nuclear RNA clusters being a common pathological feature. Yet, investigations...
4.
Godinho B, Knox E, Hildebrand S, Gilbert J, Echeverria D, Kennedy Z, et al.
Mol Ther Nucleic Acids
. 2022 Jul;
29:116-132.
PMID: 35795486
Effective systemic delivery of small interfering RNAs (siRNAs) to tissues other than liver remains a challenge. siRNAs are small (∼15 kDa) and therefore rapidly cleared by the kidneys, resulting in...
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Ferguson C, Godinho B, Alterman J, Coles A, Hassler M, Echeverria D, et al.
JCI Insight
. 2021 Dec;
6(24).
PMID: 34935646
siRNAs comprise a class of drugs that can be programmed to silence any target gene. Chemical engineering efforts resulted in development of divalent siRNAs (di-siRNAs), which support robust and long-term...
6.
Borchard S, Raschke S, Zak K, Eberhagen C, Einer C, Weber E, et al.
Life Sci Alliance
. 2021 Dec;
5(3).
PMID: 34857647
In Wilson disease, excessive copper accumulates in patients' livers and may, upon serum leakage, severely affect the brain according to current viewpoints. Present remedies aim at avoiding copper toxicity by...
7.
Alterman J, Godinho B, Hassler M, Ferguson C, Echeverria D, Sapp E, et al.
Nat Biotechnol
. 2019 Aug;
37(8):884-894.
PMID: 31375812
Sustained silencing of gene expression throughout the brain using small interfering RNAs (siRNAs) has not been achieved. Here we describe an siRNA architecture, divalent siRNA (di-siRNA), that supports potent, sustained...
8.
Haraszti R, Miller R, Dubuke M, Rockwell H, Coles A, Sapp E, et al.
iScience
. 2019 Jun;
16:230-241.
PMID: 31195240
Exosomes can serve as delivery vehicles for advanced therapeutics. The components necessary and sufficient to support exosomal delivery have not been established. Here we connect biochemical composition and activity of...
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Osborn M, Coles A, Biscans A, Haraszti R, Roux L, Davis S, et al.
Nucleic Acids Res
. 2018 Dec;
47(3):1070-1081.
PMID: 30535404
Efficient delivery of therapeutic RNA beyond the liver is the fundamental obstacle preventing its clinical utility. Lipid conjugation increases plasma half-life and enhances tissue accumulation and cellular uptake of small...
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Turanov A, Lo A, Hassler M, Makris A, Ashar-Patel A, Alterman J, et al.
Nat Biotechnol
. 2018 Nov;
PMID: 30451990
Preeclampsia is a placentally induced hypertensive disorder of pregnancy that is associated with substantial morbidity and mortality to mothers and fetuses. Clinical manifestations of preterm preeclampsia result from excess circulating...