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Matthew P Nicholas

Explore the profile of Matthew P Nicholas including associated specialties, affiliations and a list of published articles. Areas
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Articles 12
Citations 327
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Recent Articles
1.
Kalavar M, Lovett Jr E, Nicholas M, Ross-Hirsch A, Nirwan R, Sridhar J, et al.
Am J Ophthalmol . 2024 Jun; 267:135-141. PMID: 38880376
Purpose: To assess the scope of U.S.-based companies advertising and administering non-Federal Drug Administration (FDA) approved cell-based therapy (herein called NFACT) for ocular conditions based on information from companies' public...
2.
Nicholas M, Vaz T, Idrees S, Shareef S
J Glaucoma . 2021 Apr; 30(7):e344-e346. PMID: 33826601
A 57-year-old woman presented with photophobia and complaint of a persistent white light in the inferior field of her left eye for 18 months following laser peripheral iridotomy both eyes....
3.
Nicholas M, Mysore N
Exp Eye Res . 2020 Nov; 202:108363. PMID: 33221371
The optical clarity of the cornea is essential for maintaining good visual acuity. Corneal neovascularization, which is a major cause of vision loss worldwide, leads to corneal opacification and often...
4.
Brenner S, Berger F, Rao L, Nicholas M, Gennerich A
Sci Adv . 2020 Apr; 6(15):eaaz4295. PMID: 32285003
Cytoplasmic dynein is a highly complex motor protein that generates forces toward the minus end of microtubules. Using optical tweezers, we demonstrate that the low processivity (ability to take multiple...
5.
Rao L, Berger F, Nicholas M, Gennerich A
Nat Commun . 2019 Jul; 10(1):3332. PMID: 31350388
Cytoplasmic dynein is the most complex cytoskeletal motor protein and is responsible for numerous biological functions. Essential to dynein's function is its capacity to respond anisotropically to tension, so that...
6.
Nicholas M, Berger F, Rao L, Brenner S, Cho C, Gennerich A
Proc Natl Acad Sci U S A . 2015 May; 112(20):6371-6. PMID: 25941405
Cytoplasmic dynein is a homodimeric microtubule (MT) motor protein responsible for most MT minus-end-directed motility. Dynein contains four AAA+ ATPases (AAA: ATPase associated with various cellular activities) per motor domain...
7.
Nicholas M, Hook P, Brenner S, Wynne C, Vallee R, Gennerich A
Nat Commun . 2015 Feb; 6:6206. PMID: 25670086
Cytoplasmic dynein is a microtubule motor involved in cargo transport, nuclear migration and cell division. Despite structural conservation of the dynein motor domain from yeast to higher eukaryotes, the extensively...
8.
ORourke B, Gomez-Ferreria M, Berk R, Hackl A, Nicholas M, ORourke S, et al.
PLoS One . 2014 Jun; 9(6):e101001. PMID: 24971877
Cep192 is a centrosomal protein that contributes to the formation and function of the mitotic spindle in mammalian cells. Cep192's mitotic activities stem largely from its role in the recruitment...
9.
Nicholas M, Rao L, Gennerich A
Methods Mol Biol . 2014 Mar; 1136:171-246. PMID: 24633799
Numerous microtubule-associated molecular motors, including several kinesins and cytoplasmic dynein, produce opposing forces that regulate spindle and chromosome positioning during mitosis. The motility and force generation of these motors are...
10.
Nicholas M, Rao L, Gennerich A
Methods Mol Biol . 2014 Mar; 1136:137-69. PMID: 24633798
Rigid attachment of microtubules (MTs) to glass cover slip surfaces is a prerequisite for a variety of microscopy experiments in which MTs are used as substrates for MT-associated proteins, such...