Matthew P DeLisa
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Explore the profile of Matthew P DeLisa including associated specialties, affiliations and a list of published articles.
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150
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3132
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Recent Articles
1.
Kuo J, Colville M, Sorkin M, Kuo J, Huang L, Thornlow D, et al.
ACS Cent Sci
. 2025 Mar;
11(2):193-207.
PMID: 40028367
Complex carbohydrates called glycans play crucial roles in regulating cell and tissue physiology, but how they map to nanoscale anatomical features must still be resolved. Here, we present the first...
2.
Wang W, Bunyatov M, Lopez-Barbosa N, DeLisa M
bioRxiv
. 2025 Mar;
PMID: 40027839
Monoclonal antibodies (mAbs) that specifically recognize cell surface glycans associated with cancer and infectious disease hold tremendous value for both basic research and clinical applications. However, high-quality anti-glycan mAbs, especially...
3.
Thaiprayoon A, Chantarasorn Y, Oonanant W, Kasorn A, Longsompurana P, Tapaneeyakorn S, et al.
Sci Rep
. 2025 Jan;
15(1):3594.
PMID: 39875480
Nanobodies (Nbs) hold great potential to replace conventional antibodies in various biomedical applications. However, conventional methods for their discovery can be time-consuming and expensive. We have developed a reliable protein...
4.
Bhat S, Palepu K, Hong L, Mao J, Ye T, Iyer R, et al.
Sci Adv
. 2025 Jan;
11(4):eadr8638.
PMID: 39841846
Designing binders to target undruggable proteins presents a formidable challenge in drug discovery. In this work, we provide an algorithmic framework to design short, target-binding linear peptides, requiring only the...
5.
Wong D, Shaver Z, Cabezas M, Daniel-Ivad M, Warfel K, Prasanna D, et al.
bioRxiv
. 2024 Dec;
PMID: 39651187
Post-translational modifications (PTMs) are important for the stability and function of many therapeutic proteins and peptides. Current methods for studying and engineering PTM installing proteins often suffer from low-throughput experimental...
6.
Programmable protein degraders enable selective knockdown of pathogenic β-catenin subpopulations and
Ye T, Alamgir A, Robertus C, Colina D, Monticello C, Donahue T, et al.
bioRxiv
. 2024 Nov;
PMID: 39605463
Aberrant activation of Wnt signaling results in unregulated accumulation of cytosolic β-catenin, which subsequently enters the nucleus and promotes transcription of genes that contribute to cellular proliferation and malignancy. Here,...
7.
Sotomayor B, Donahue T, Mahajan S, Taw M, Hulbert S, Bidstrup E, et al.
bioRxiv
. 2024 Nov;
PMID: 39574765
Human immunoglobulin G (IgG) antibodies are one of the most important classes of biotherapeutic agents and undergo glycosylation at the conserved N297 site in the C2 domain, which is critical...
8.
Weyant K, Oloyede A, DeLisa M
Methods Mol Biol
. 2024 Aug;
2843:195-216.
PMID: 39141302
Engineered outer membrane vesicles (OMVs) derived from Gram-negative bacteria are a promising vaccine technology for developing immunity against diverse pathogens. However, antigen display on OMVs can be challenging to control...
9.
Hong L, Ye T, Wang T, Srijay D, Zhao L, Watson R, et al.
Res Sq
. 2024 Aug;
PMID: 39108486
Dysregulated protein degradation via the ubiquitin-proteasomal pathway can induce numerous disease phenotypes, including cancer, neurodegeneration, and diabetes. Stabilizing improperly ubiquitinated proteins via target-specific deubiquitination is thus a critical therapeutic goal....
10.
Bhat S, Palepu K, Hong L, Mao J, Ye T, Iyer R, et al.
bioRxiv
. 2024 Aug;
PMID: 39091799
Designing binders to target undruggable proteins presents a formidable challenge in drug discovery, requiring innovative approaches to overcome the lack of putative binding sites. Recently, generative models have been trained...