Matthew L Steinhauser
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Explore the profile of Matthew L Steinhauser including associated specialties, affiliations and a list of published articles.
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61
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3625
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Recent Articles
1.
Gurkar A, Okawa S, Guillermier C, Chaddha K, Steinhauser M
Aging Cell
. 2025 Feb;
:e70015.
PMID: 39968744
Senescence is a cell fate associated with age-related pathologies; however, senescence markers are not well-defined. Using single cell multi-isotope imaging mass spectrometry (MIMS), we identified hypercondensed, transcriptionally silent DNA globules...
2.
Kumar G, Wang R, Sharma A, David N, Amorim T, Sinden D, et al.
Nat Commun
. 2025 Feb;
16(1):1330.
PMID: 39900947
Physiological adaptations to fasting enable humans to survive for prolonged periods without food and involve molecular pathways that may drive life-prolonging effects of dietary restriction in model organisms. Mobilization of...
3.
Zhang Y, David N, Pesaresi T, Andrews R, Kumar G, Chen H, et al.
JCI Insight
. 2024 Dec;
10(2).
PMID: 39656538
Mechanisms underpinning signals from genome-wide association studies remain poorly understood, particularly for noncoding variation and for complex diseases such as type 2 diabetes mellitus (T2D) where pathogenic mechanisms in multiple...
4.
Steinhauser M, Maron B
JACC Basic Transl Sci
. 2024 Nov;
9(10):1252-1263.
PMID: 39534642
Fibroproliferative remodeling of distal pulmonary arterioles is a cornerstone characteristic of pulmonary arterial hypertension (PAH). Data from contemporary quantitative imaging suggest that anabolic synthesis of macromolecular substrate, defined here as...
5.
Bomba-Warczak E, Velez K, Zhou L, Guillermier C, Edassery S, Steinhauser M, et al.
Elife
. 2024 Oct;
13.
PMID: 39480006
The mechanisms contributing to age-related deterioration of the female reproductive system are complex, however aberrant protein homeostasis is a major contributor. We elucidated exceptionally stable proteins, structures, and macromolecules that...
6.
Quaytman J, David N, Venugopal S, Amorim T, Beatrice B, Toledo F, et al.
Contemp Clin Trials
. 2024 Sep;
146:107698.
PMID: 39299543
Background: Caloric restriction prolongs lifespan in model organisms and improves metrics of aging-related diseases in humans, but daily compliance is challenging. Intermittent fasting improves metrics of lipid and glucose metabolism...
7.
Guillermier C, Kumar N, Bracken R, Alvarez D, OKeefe J, Gurkar A, et al.
Life Sci Alliance
. 2024 Sep;
7(12).
PMID: 39288993
The three-dimensional structure of DNA is a biophysical determinant of transcription. The density of chromatin condensation is one determinant of transcriptional output. Chromatin condensation is generally viewed as enforcing transcriptional...
8.
Steinhauser M
J Clin Invest
. 2024 Sep;
134(17).
PMID: 39225094
Obesity is a known driver of endometrial cancer. In this issue of the JCI, Gómez-Banoy and colleagues investigated a cohort of patients with advanced endometrial cancer treated with immune checkpoint...
9.
Zhu B, Liu S, David N, Dion W, Doshi N, Siegel L, et al.
NPJ Biol Timing Sleep
. 2024 Aug;
1(1):4.
PMID: 39148626
Mice and many marine organisms exhibit ~12-h ultradian rhythms, however, direct evidence of ~12-h ultradian rhythms in humans is lacking. Here, we performed prospective, temporal transcriptome profiling of peripheral white...
10.
Bracken R, Davison L, Buehler D, Fulton M, Carson E, Sheng Q, et al.
iScience
. 2024 Jun;
27(6):110011.
PMID: 38868181
Combinatorial signaling by proinflammatory cytokines synergizes to exacerbate toxicity to cells and tissue injury during acute infections. To explore synergism at the gene-regulatory level, we investigated the dynamics of transcription...