Matthew L Baker
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Explore the profile of Matthew L Baker including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
McPherson J, Hurdle J, Baker M, Hussain T, Kumar A, Garey K
Antimicrob Agents Chemother
. 2025 Feb;
:e0167924.
PMID: 39982073
Ibezapolstat (IBZ), a first-in-class antibiotic targeting the PolC-type DNA polymerase III alpha-subunit (PolC) in low G + C bacteria, is in clinical development for the treatment of infection (CDI). In...
2.
Lawson C, Kryshtafovych A, Pintilie G, Burley S, cerny J, Chen V, et al.
Nat Methods
. 2024 Jun;
21(7):1340-1348.
PMID: 38918604
The EMDataResource Ligand Model Challenge aimed to assess the reliability and reproducibility of modeling ligands bound to protein and protein-nucleic acid complexes in cryogenic electron microscopy (cryo-EM) maps determined at...
3.
Lawson C, Kryshtafovych A, Pintilie G, Burley S, cerny J, Chen V, et al.
Res Sq
. 2024 Feb;
PMID: 38343795
The EMDataResource Ligand Model Challenge aimed to assess the reliability and reproducibility of modeling ligands bound to protein and protein/nucleic-acid complexes in cryogenic electron microscopy (cryo-EM) maps determined at near-atomic...
4.
Corum M, Venkannagari H, Hryc C, Baker M
Biophys J
. 2024 Jan;
123(4):435-450.
PMID: 38268190
Over the last 15 years, structural biology has seen unprecedented development and improvement in two areas: electron cryo-microscopy (cryo-EM) and predictive modeling. Once relegated to low resolutions, single-particle cryo-EM is...
5.
Jia X, Gao Y, Huang Y, Sun L, Li S, Li H, et al.
Nat Commun
. 2023 Nov;
14(1):7481.
PMID: 37980340
Baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) has been widely used as a bioinsecticide and a protein expression vector. Despite their importance, very little is known about the structure of most...
6.
Hryc C, Mallampalli V, Bovshik E, Azinas S, Fan G, Serysheva I, et al.
Nat Commun
. 2023 May;
14(1):2783.
PMID: 37188665
Cardiolipin is a hallmark phospholipid of mitochondrial membranes. Despite established significance of cardiolipin in supporting respiratory supercomplex organization, a mechanistic understanding of this lipid-protein interaction is still lacking. To address...
7.
Zhang Q, Gao Y, Baker M, Liu S, Jia X, Xu H, et al.
PLoS Pathog
. 2023 Apr;
19(4):e1011341.
PMID: 37083840
Infecting a wide range of hosts, members of Reovirales (formerly Reoviridae) consist of a genome with different numbers of segmented double stranded RNAs (dsRNA) encapsulated by a proteinaceous shell and...
8.
Fan G, Baker M, Terry L, Arige V, Chen M, Seryshev A, et al.
Nat Commun
. 2022 Nov;
13(1):6942.
PMID: 36376291
Inositol-1,4,5-trisphosphate receptors (IPRs) are activated by IP and Ca and their gating is regulated by various intracellular messengers that finely tune the channel activity. Here, using single particle cryo-EM analysis...
9.
Hryc C, Baker M
Biomolecules
. 2022 Jun;
12(6).
PMID: 35740898
Single-particle electron cryomicroscopy (cryoEM) has become an indispensable tool for studying structure and function in macromolecular assemblies. As an integral part of the cryoEM structure determination process, computational tools have...
10.
Hryc C, Baker M
iScience
. 2022 Jun;
25(7):104496.
PMID: 35733789
With the advent of new artificial intelligence and machine learning algorithms, predictive modeling can, in some cases, produce structures on par with experimental methods. The combination of predictive modeling and...