Matthew J Wakefield
Overview
Explore the profile of Matthew J Wakefield including associated specialties, affiliations and a list of published articles.
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62
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5900
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Recent Articles
21.
Jung M, Gao J, Cheung L, Bongers A, Somers K, Clifton M, et al.
Int J Cancer
. 2020 Apr;
147(8):2225-2238.
PMID: 32277480
Epithelial ovarian cancer (EOC) is a complex disease comprising discrete histological and molecular subtypes, for which survival rates remain unacceptably low. Tailored approaches for this deadly heterogeneous disease are urgently...
22.
Gorringe K, Cheasley D, Wakefield M, Ryland G, Allan P, Alsop K, et al.
Gynecol Oncol
. 2020 Jan;
156(3):552-560.
PMID: 31902686
Objective: Mucinous ovarian carcinoma (MOC) is an uncommon ovarian cancer histotype that responds poorly to conventional chemotherapy regimens. Although long overall survival outcomes can occur with early detection and optimal...
23.
Cheasley D, Wakefield M, Ryland G, Allan P, Alsop K, Amarasinghe K, et al.
Nat Commun
. 2019 Sep;
10(1):3935.
PMID: 31477716
Mucinous ovarian carcinoma (MOC) is a unique subtype of ovarian cancer with an uncertain etiology, including whether it genuinely arises at the ovary or is metastatic disease from other organs....
24.
Fisicaro N, Salvaris E, Philip G, Wakefield M, Nottle M, Hawthorne W, et al.
Xenotransplantation
. 2019 Aug;
27(1):e12551.
PMID: 31407391
Gene editing using clustered regularly interspaced short palindromic repeats/Cas9 has great potential for improving the compatibility of porcine organs with human recipients. However, the risk of detrimental off-target mutations in...
25.
Chan W, Komada M, Fukushima T, Southard-Smith E, Anderson C, Wakefield M
Sci Rep
. 2019 Mar;
9(1):3929.
PMID: 30850723
Adrenal chromaffin cells and sympathetic neurons synthesize and release catecholamines, and both cell types are derived from neural crest precursors. However, they have different developmental histories, with sympathetic neurons derived...
26.
Kondrashova O, Topp M, Nesic K, Lieschke E, Ho G, Harrell M, et al.
Nat Commun
. 2018 Sep;
9(1):3970.
PMID: 30266954
Accurately identifying patients with high-grade serous ovarian carcinoma (HGSOC) who respond to poly(ADP-ribose) polymerase inhibitor (PARPi) therapy is of great clinical importance. Here we show that quantitative BRCA1 methylation analysis...
27.
Janic A, Valente L, Wakefield M, Stefano L, Milla L, Wilcox S, et al.
Nat Med
. 2018 Jun;
24(7):947-953.
PMID: 29892060
It has long been assumed that p53 suppresses tumor development through induction of apoptosis, possibly with contributions by cell cycle arrest and cell senescence. However, combined deficiency in these three...
28.
Kondrashova O, Nguyen M, Shield-Artin K, Tinker A, Teng N, Harrell M, et al.
Cancer Discov
. 2017 Jun;
7(9):984-998.
PMID: 28588062
High-grade epithelial ovarian carcinomas containing mutated or () homologous recombination (HR) genes are sensitive to platinum-based chemotherapy and PARP inhibitors (PARPi), while restoration of HR function due to secondary mutations...
29.
Liddelow S, Dziegielewska K, Ek C, Habgood M, Bauer H, Bauer H, et al.
PLoS One
. 2016 Jan;
11(1):e0147680.
PMID: 26783757
No abstract available.
30.
Molyneux P, Kilvington S, Wakefield M, Prydal J, Bannister N
Cornea
. 2015 Oct;
34(12):1588-92.
PMID: 26488626
Purpose: Acanthamoeba keratitis can cause devastating damage to the human cornea and is often difficult to diagnose by routine clinical methods. In this preliminary study, we investigated whether Acanthamoeba may...