Matthew Ishahak
Overview
Explore the profile of Matthew Ishahak including associated specialties, affiliations and a list of published articles.
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13
Citations
156
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Recent Articles
1.
Ishahak M, Han R, Annamalai D, Woodiwiss T, McCornack C, Cleary R, et al.
Adv Sci (Weinh)
. 2025 Jan;
12(10):e2410110.
PMID: 39836549
Glioblastoma (GBM) is an aggressive form of brain cancer that is highly resistant to therapy due to significant intra-tumoral heterogeneity. The lack of robust in vitro models to study early...
2.
Ishahak M, Han R, Annamalai D, Woodiwiss T, McCornack C, Cleary R, et al.
bioRxiv
. 2024 Aug;
PMID: 39211284
Glioblastoma (GBM) is an aggressive form of brain cancer that is highly resistant to therapy due to significant intra-tumoral heterogeneity. The lack of robust in vitro models to study early...
3.
Maestas M, Ishahak M, Augsornworawat P, Veronese-Paniagua D, Maxwell K, Velazco-Cruz L, et al.
Nat Commun
. 2024 Jul;
15(1):5567.
PMID: 38956087
Diabetes involves the death or dysfunction of pancreatic β-cells. Analysis of bulk sequencing from human samples and studies using in vitro and in vivo models suggest that endoplasmic reticulum and...
4.
Alver C, Drabbe E, Ishahak M, Agarwal A
Nat Commun
. 2024 Jun;
15(1):5118.
PMID: 38879554
Organ on Chip platforms hold significant promise as alternatives to animal models or traditional cell cultures, both of which poorly recapitulate human pathophysiology and human level responses. Within the last...
5.
Schmidt M, Ishahak M, Augsornworawat P, Millman J
BMC Genomics
. 2024 Jan;
25(1):105.
PMID: 38267908
Diabetes cell replacement therapy has the potential to be transformed by human pluripotent stem cell-derived β cells (SC-β cells). However, the precise identity of SC-β cells in relationship to primary...
6.
Richardson T, Pettway Y, Walker J, Nelson H, Ishahak M, Poffenberger G, et al.
J Vis Exp
. 2023 Nov;
(201).
PMID: 37982512
The pancreatic islets of Langerhans, which are small 3D collections of specialized endocrine and supporting cells interspersed throughout the pancreas, have a central role in the control of glucose homeostasis...
7.
Augsornworawat P, Hogrebe N, Ishahak M, Schmidt M, Marquez E, Maestas M, et al.
Nat Cell Biol
. 2023 Aug;
25(10):1546.
PMID: 37558893
No abstract available.
8.
Augsornworawat P, Hogrebe N, Ishahak M, Schmidt M, Marquez E, Maestas M, et al.
Nat Cell Biol
. 2023 May;
25(6):904-916.
PMID: 37188763
Insulin-producing β cells created from human pluripotent stem cells have potential as a therapy for insulin-dependent diabetes, but human pluripotent stem cell-derived islets (SC-islets) still differ from their in vivo...
9.
Hogrebe N, Ishahak M, Millman J
Cell Stem Cell
. 2023 May;
30(5):530-548.
PMID: 37146579
The generation of islet-like endocrine clusters from human pluripotent stem cells (hPSCs) has the potential to provide an unlimited source of insulin-producing β cells for the treatment of diabetes. In...
10.
Ishahak M, Hill J, Amin Q, Wubker L, Hernandez A, Mitrofanova A, et al.
Front Bioeng Biotechnol
. 2020 Dec;
8:581163.
PMID: 33304889
Microphysiological systems, also known as organs-on-chips, are microfluidic devices designed to model human physiology . Polydimethylsiloxane (PDMS) is the most widely used material for organs-on-chips due to established microfabrication methods,...