Matthew G Oser
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Explore the profile of Matthew G Oser including associated specialties, affiliations and a list of published articles.
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27
Citations
1054
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Recent Articles
1.
Singh S, Gleason C, Fang M, Laimon Y, Khivansara V, Xie S, et al.
bioRxiv
. 2024 Aug;
PMID: 39211113
Cancer cell proliferation requires precise control of E2F1 activity; excess activity promotes apoptosis. Here, we developed cell-permeable and bioavailable macrocycles that selectively kill small cell lung cancer (SCLC) cells with...
2.
Duplaquet L, So K, Ying A, Pal Choudhuri S, Li X, Xu G, et al.
Cancer Cell
. 2024 Jul;
42(8):1352-1369.e13.
PMID: 39029464
Small cell lung cancers (SCLCs) are composed of heterogeneous subtypes marked by lineage-specific transcription factors, including ASCL1, NEUROD1, and POU2F3. POU2F3-positive SCLCs, ∼12% of all cases, are uniquely dependent on...
3.
El Zarif T, Meador C, Qiu X, Seo J, Davidsohn M, Savignano H, et al.
Clin Cancer Res
. 2024 Jun;
30(17):3798-3811.
PMID: 38912901
Purpose: Histologic transformation to small cell lung cancer (SCLC) is a mechanism of treatment resistance in patients with advanced oncogene-driven lung adenocarcinoma (LUAD) that currently requires histologic review for diagnosis....
4.
Singh P, Gu W, Madha S, Lynch A, Cejas P, He R, et al.
Cell Stem Cell
. 2024 May;
31(7):1038-1057.e11.
PMID: 38733993
Enteroendocrine cells (EECs) secrete serotonin (enterochromaffin [EC] cells) or specific peptide hormones (non-EC cells) that serve vital metabolic functions. The basis for terminal EEC diversity remains obscure. By forcing activity...
5.
Cai L, Gao Y, DeBerardinis R, Acquaah-Mensah G, Aidinis V, Beane J, et al.
bioRxiv
. 2024 Mar;
PMID: 38464291
Lung cancer, the leading cause of cancer mortality, exhibits diverse histological subtypes and genetic complexities. Numerous preclinical mouse models have been developed to study lung cancer, but data from these...
6.
Duplaquet L, So K, Ying A, Li X, Li Y, Qiu X, et al.
bioRxiv
. 2024 Feb;
PMID: 38328215
Small cell lung cancers (SCLC) are comprised of heterogeneous subtypes marked by lineage-specific transcription factors, including ASCL1, NEUROD1, and POU2F3. POU2F3-positive SCLC, ∼12% of all cases, are uniquely dependent on...
7.
Singh P, Gu W, Madha S, Lynch A, Cejas P, He R, et al.
bioRxiv
. 2024 Jan;
PMID: 38260422
Enteroendocrine cells (EECs), which secrete serotonin (enterochromaffin cells, EC) or a dominant peptide hormone, serve vital physiologic functions. As with any adult human lineage, the basis for terminal cell diversity...
8.
Oser M, MacPherson D, Oliver T, Sage J, Park K
Oncogene
. 2024 Jan;
43(7):457-469.
PMID: 38191672
Small cell lung cancer (SCLC) remains the most fatal form of lung cancer, with patients in dire need of new and effective therapeutic approaches. Modeling SCLC in an immunocompetent host...
9.
Baca S, Seo J, Davidsohn M, Fortunato B, Semaan K, Sotudian S, et al.
Nat Med
. 2023 Dec;
30(3):907.
PMID: 38049623
No abstract available.
10.
Li Y, Mahadevan N, Duplaquet L, Hong D, Durmaz Y, Jones K, et al.
Cell Rep Med
. 2023 Nov;
4(11):101282.
PMID: 37992688
Despite small cell lung cancers (SCLCs) having a high mutational burden, programmed death-ligand 1 (PD-L1) immunotherapy only modestly increases survival. A subset of SCLCs that lose their ASCL1 neuroendocrine phenotype...