Author: Matthew Frieman

1.

Extracellular vesicles containing SARS-CoV-2 proteins are associated with multi-organ dysfunction and worse outcomes in patients with severe COVID-19

de Miguel-Perez D, Arroyo-Hernandez M, La Salvia S, Gunasekaran M, Pickering E, Avila S, et al.

J Extracell Vesicles . 2024 Nov; 13(11):e70001. PMID: 39558820

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) and has been related to more than 7 million deaths globally since 2019. The association of high...

2.

Comparative analysis of SARS-CoV-2 neutralization titers reveals consistency between human and animal model serum and across assays

Muhlemann B, Wilks S, Baracco L, Bekliz M, Carreno J, Corman V, et al.

Sci Transl Med . 2024 May; 16(747):eadl1722. PMID: 38748773

The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires ongoing monitoring to judge the ability of newly arising variants to escape the immune response. A surveillance system necessitates...

3.

Association of Nirmatrelvir/Ritonavir Treatment and COVID-19-Neutralizing Antibody Titers in a Longitudinal Health Care Worker Cohort

Decker S, Xiao S, Dillen C, Schumacher C, Milstone A, Frieman M, et al.

Open Forum Infect Dis . 2024 Feb; 11(2):ofad625. PMID: 38352152

Nirmatrelvir/ritonavir (NMV/r) is used for the treatment of coronavirus disease 2019 (COVID-19) infection. However, rebound COVID-19 infections can occur after taking NMV/r. We examined neutralizing antibodies to the severe acute...

4.

SIRT-1 is required for release of enveloped enteroviruses

Jassey A, Logue J, Weston S, Wagner M, Galitska G, Miller K, et al.

Elife . 2023 Oct; 12. PMID: 37850626

Enterovirus D68 (EV-D68) is a re-emerging enterovirus that causes acute respiratory illness in infants and has recently been linked to Acute Flaccid Myelitis. Here, we show that the histone deacetylase,...

5.

Diet-induced obesity and diabetes enhance mortality and reduce vaccine efficacy for SARS-CoV-2

Johnson R, Ardanuy J, Hammond H, Logue J, Jackson L, Baracco L, et al.

J Virol . 2023 Oct; 97(11):e0133623. PMID: 37846985

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused a wide spectrum of diseases in the human population, from asymptomatic infections to death. It is important to study the host differences...

6.

Comparative Analysis of SARS-CoV-2 Antigenicity across Assays and in Human and Animal Model Sera

Muhlemann B, Wilks S, Baracco L, Bekliz M, Carreno J, Corman V, et al.

bioRxiv . 2023 Oct; PMID: 37808679

The antigenic evolution of SARS-CoV-2 requires ongoing monitoring to judge the immune escape of newly arising variants. A surveillance system necessitates an understanding of differences in neutralization titers measured in...

7.

Pyronaridine tetraphosphate is an efficacious antiviral and anti-inflammatory active against multiple highly pathogenic coronaviruses

Ardanuy J, Johnson R, Dillen C, Taylor L, Hammond H, Weston S, et al.

mBio . 2023 Aug; 14(5):e0158723. PMID: 37581442

Pyronaridine tetraphosphate is on the WHO Essential Medicine List for its importance as a widely available and safe treatment for malaria. We find that pyronaridine is a highly effective antiviral...

8.

Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients

Sperry M, Oskotsky T, Maric I, Kaushal S, Takeda T, Horvath V, et al.

PLoS Comput Biol . 2023 May; 19(5):e1011050. PMID: 37146076

Drug repurposing requires distinguishing established drug class targets from novel molecule-specific mechanisms and rapidly derisking their therapeutic potential in a time-critical manner, particularly in a pandemic scenario. In response to...

9.

Virology under the Microscope-a Call for Rational Discourse

Goodrum F, Lowen A, Lakdawala S, Alwine J, Casadevall A, Imperiale M, et al.

mSphere . 2023 Jan; 8(2):e0003423. PMID: 36700653

Viruses have brought humanity many challenges: respiratory infection, cancer, neurological impairment and immunosuppression to name a few. Virology research over the last 60+ years has responded to reduce this disease...

10.

Virology under the Microscope-a Call for Rational Discourse

Goodrum F, Lowen A, Lakdawala S, Alwine J, Casadevall A, Imperiale M, et al.

mBio . 2023 Jan; 14(1):e0018823. PMID: 36700642

Viruses have brought humanity many challenges: respiratory infection, cancer, neurological impairment and immunosuppression to name a few. Virology research over the last 60+ years has responded to reduce this disease...