Matthew Freer
Overview
Explore the profile of Matthew Freer including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
46
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0
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Recent Articles
1.
Freer M, Cooper J, Goncalves K, Przyborski S
Cells
. 2024 Nov;
13(22).
PMID: 39594608
Drug discovery is associated with high levels of compound elimination in all stages of development. The current practices for the pharmacokinetic testing of intestinal absorption combine Transwell inserts with the...
2.
Cedrone E, Ishaq A, Grabarnik E, Edmondson E, Skoczen S, Neun B, et al.
Nanomedicine
. 2024 Aug;
62:102780.
PMID: 39181221
Palmar-plantar erythrodysesthesia (PPE), also known as hand and foot syndrome, is a condition characterized by inflammation-mediated damage to the skin on the palms and soles of the hands and feet....
3.
Ahmed S, Ahmed M, Ishaq A, Freer M, Stebbings R, Dickinson A
Toxics
. 2024 Jun;
12(6).
PMID: 38922081
Material And Methods: Immune responses were determined by T cell proliferation and multiplex cytokine analysis, as well as histopathological analysis of skin damage (grades I-IV in increasing severity), predicting a...
4.
Martins-Ribeiro A, Kizhedath A, Ahmed S, Glassey J, Ishaq A, Freer M, et al.
Toxics
. 2024 May;
12(5).
PMID: 38787111
Monoclonal antibodies (mAbs) are important therapeutics. However, the enhanced potential for aggregation has become a critical quality parameter during the production of mAbs. Furthermore, mAb aggregation may also present a...
5.
Anzai T, Myatt G, Hall F, Finney B, Nakagawa K, Iwata H, et al.
J Toxicol Pathol
. 2024 Apr;
37(2):45-53.
PMID: 38584971
The United States Senate passed the "FDA Modernization Act 2.0." on September 29, 2022. Although the effectiveness of this Bill, which aims to eliminate the mandatory use of laboratory animals...
6.
Freer M, Darling N, Goncalves K, Mills K, Przyborski S
Bioeng Transl Med
. 2023 May;
8(3):e10484.
PMID: 37206205
Human skin equivalents (HSEs) are an increasingly popular research tool due to limitations associated with animal testing for dermatological research. They recapitulate many aspects of skin structure and function, however,...
7.
Costello L, Darling N, Freer M, Bradbury S, Mobbs C, Przyborski S
Methods Mol Biol
. 2021 Feb;
2273:279-296.
PMID: 33604861
In vitro epithelial models are valuable tools for both academic and industrial laboratories to investigate tissue physiology and disease. Epithelial tissues comprise the surface epithelium, basement membrane, and underlying supporting...
8.
Darling N, Mobbs C, Gonzalez-Hau A, Freer M, Przyborski S
Front Bioeng Biotechnol
. 2020 Sep;
8:992.
PMID: 32984279
The Caco-2 monolayer is the most widely used model of the human intestinal mucosa to study absorption. However, models lack communication from other cells present in the native intestine, such...