Matthew D Shirley
Overview
Explore the profile of Matthew D Shirley including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
699
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0
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Recent Articles
1.
Elbatsh A, Amin-Mansour A, Haberkorn A, Textor C, Ebel N, Renard E, et al.
Nat Cancer
. 2024 Jan;
5(3):481-499.
PMID: 38233483
Activating mutations in GNAQ/GNA11 occur in over 90% of uveal melanomas (UMs), the most lethal melanoma subtype; however, targeting these oncogenes has proven challenging and inhibiting their downstream effectors show...
2.
Crowe M, Zavorotinskaya T, Voliva C, Shirley M, Wang Y, Ruddy D, et al.
Mol Cancer Res
. 2021 Mar;
19(6):1063-1075.
PMID: 33707308
Half of advanced human melanomas are driven by mutant BRAF and dependent on MAPK signaling. Interestingly, the results of three independent genetic screens highlight a dependency of BRAF-mutant melanoma cell...
3.
Wang H, Mulford I, Sharp F, Liang J, Kurtulus S, Trabucco G, et al.
Cancer Res
. 2021 Jan;
81(11):3079-3091.
PMID: 33504557
p53 is a transcription factor that plays a central role in guarding the genomic stability of cells through cell-cycle arrest or induction of apoptosis. However, the effects of p53 in...
4.
Rago F, Elliott G, Li A, Sprouffske K, Kerr G, Desplat A, et al.
Mol Cancer Ther
. 2020 Aug;
19(10):2186-2195.
PMID: 32747420
Uveal melanoma is a rare and aggressive cancer that originates in the eye. Currently, there are no approved targeted therapies and very few effective treatments for this cancer. Although activating...
5.
Leung G, Feng T, Sigoillot F, Geyer F, Shirley M, Ruddy D, et al.
Mol Cancer Res
. 2018 Sep;
17(1):199-211.
PMID: 30201825
The most frequent genetic alterations in melanoma are gain-of-function (GOF) mutations in BRAF, which result in RAF-MEK-ERK signaling pathway addiction. Despite therapeutic success of RAF and MEK inhibitors in treating...
6.
Munoz D, Cassiani P, Li L, Billy E, Korn J, Jones M, et al.
Cancer Discov
. 2016 Jun;
6(8):900-13.
PMID: 27260157
Unlabelled: CRISPR/Cas9 has emerged as a powerful new tool to systematically probe gene function. We compared the performance of CRISPR to RNAi-based loss-of-function screens for the identification of cancer dependencies...
7.
Shirley M, Frelin L, Soria Lopez J, Jedlicka A, Dziedzic A, Frank-Crawford M, et al.
PLoS One
. 2016 Mar;
11(3):e0149646.
PMID: 26933844
Copy number variants (CNVs) were detected and analyzed in 14 probands with autism and intellectual disability with self-injurious behavior (SIB) resulting in tissue damage. For each proband we obtained a...
8.
9.
Baugher J, Baugher B, Shirley M, Pevsner J
BMC Genomics
. 2013 Jun;
14:367.
PMID: 23724825
Background: Mosaic somatic alterations are present in all multi-cellular organisms, but the physiological effects of low-level mosaicism are largely unknown. Most mosaic alterations remain undetectable with current analytical approaches, although...
10.
Shirley M, Tang H, Gallione C, Baugher J, Frelin L, Cohen B, et al.
N Engl J Med
. 2013 May;
368(21):1971-9.
PMID: 23656586
Background: The Sturge-Weber syndrome is a sporadic congenital neurocutaneous disorder characterized by a port-wine stain affecting the skin in the distribution of the ophthalmic branch of the trigeminal nerve, abnormal...