Matthew C Trudeau
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Explore the profile of Matthew C Trudeau including associated specialties, affiliations and a list of published articles.
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Citations
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Recent Articles
1.
Johnson A, Trudeau M
J Pharmacol Toxicol Methods
. 2024 Sep;
130:107562.
PMID: 39332652
The Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative reassesses using the inhibition of hERG potassium channels by drugs as the major determinant for the potential to cause drug-induced Torsades de...
2.
Photoinhibition of the hERG potassium channel PAS domain by ultraviolet light speeds channel closing
Codding S, Trudeau M
Biophys J
. 2024 May;
123(16):2392-2405.
PMID: 38796698
hERG potassium channels are critical for cardiac excitability. hERG channels have a Per-Arnt-Sim (PAS) domain at their N-terminus, and here, we examined the mechanism for PAS domain regulation of channel...
3.
4.
Codding S, Trudeau M
bioRxiv
. 2024 Jan;
PMID: 38260338
Human ether-à-go-go related gene (hERG) voltage-activated potassium channels are critical for cardiac excitability. Characteristic slow closing (deactivation) in hERG is regulated by direct interaction between the N-terminal Per-Arnt-Sim (PAS) domain...
5.
Johnson A, Crawford T, Trudeau M
J Biol Chem
. 2022 Jul;
298(9):102233.
PMID: 35798139
A major physiological role of hERG1 (human Ether-á-go-go-Related Gene 1) potassium channels is to repolarize cardiac action potentials. Two isoforms, hERG1a and hERG1b, associate to form the potassium current I...
6.
Harley C, Bernardo-Seisdedos G, Stevens-Sostre W, Jones D, Azevedo M, Sampaio P, et al.
Proc Natl Acad Sci U S A
. 2021 Oct;
118(44).
PMID: 34716268
The human ERG (hERG) K channel has a crucial function in cardiac repolarization, and mutations or channel block can give rise to long QT syndrome and catastrophic ventricular arrhythmias. The...
7.
Codding S, Johnson A, Trudeau M
Channels (Austin)
. 2020 Sep;
14(1):294-309.
PMID: 32924766
The KCNH family comprises the ERG, EAG, and ELK voltage-activated, potassium-selective channels. Distinct from other K channels, KCNH channels contain unique structural domains, including a PAS (Per-Arnt-Sim) domain in the...
8.
9.
Codding S, Trudeau M
J Gen Physiol
. 2018 Nov;
151(4):478-488.
PMID: 30425124
Human ether-à-go-go-related gene (hERG, KCNH2) voltage-activated potassium channels are critical for cardiac excitability. hERG channels have characteristic slow closing (deactivation), which is auto-regulated by a direct interaction between the N-terminal...
10.
Jones D, Johnson A, Roti Roti E, Liu F, Uelmen R, Ayers R, et al.
J Cell Sci
. 2018 Mar;
131(6).
PMID: 29507111
Reduced levels of the cardiac human (h)ERG ion channel protein and the corresponding repolarizing current can cause arrhythmia and sudden cardiac death, but the underlying cellular mechanisms controlling hERG surface...