Matthew C LaFave
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Explore the profile of Matthew C LaFave including associated specialties, affiliations and a list of published articles.
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20
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1170
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Recent Articles
1.
Varshney G, Carrington B, Pei W, Bishop K, Chen Z, Fan C, et al.
Nat Protoc
. 2016 Nov;
11(12):2357-2375.
PMID: 27809318
The zebrafish is a popular model organism for studying development and disease, and genetically modified zebrafish provide an essential tool for functional genomic studies. Numerous publications have demonstrated the efficacy...
2.
Chandler R, LaFave M, Varshney G, Burgess S, Venditti C
Mol Ther
. 2016 Feb;
24(2):198-201.
PMID: 26906613
No abstract available.
3.
Vrljicak P, Tao S, Varshney G, Quach H, Joshi A, LaFave M, et al.
G3 (Bethesda)
. 2016 Jan;
6(4):805-17.
PMID: 26818075
DNA transposons and retroviruses are important transgenic tools for genome engineering. An important consideration affecting the choice of transgenic vector is their insertion site preferences. Previous large-scale analyses of Ds...
4.
Marquart G, Tabor K, Brown M, Strykowski J, Varshney G, LaFave M, et al.
Front Neural Circuits
. 2015 Dec;
9:78.
PMID: 26635538
Transgenic methods enable the selective manipulation of neurons for functional mapping of neuronal circuits. Using confocal microscopy, we have imaged the cellular-level expression of 109 transgenic lines in live 6...
5.
van Belkum A, Soriaga L, LaFave M, Akella S, Veyrieras J, Barbu E, et al.
mBio
. 2015 Nov;
6(6):e01796-15.
PMID: 26604259
Unlabelled: Pseudomonas aeruginosa is an antibiotic-refractory pathogen with a large genome and extensive genotypic diversity. Historically, P. aeruginosa has been a major model system for understanding the molecular mechanisms underlying...
6.
Seiler C, Gebhart N, Zhang Y, Shinton S, Li Y, Ross N, et al.
PLoS One
. 2015 Jul;
10(7):e0131908.
PMID: 26161877
Genetic screens are a powerful tool to discover genes that are important in immune cell development and function. The evolutionarily conserved development of lymphoid cells paired with the genetic tractability...
7.
LaFave M, Varshney G, Burgess S
Bioinformatics
. 2015 Jun;
31(19):3219-21.
PMID: 26049161
Unlabelled: There are several experimental contexts in which it is important to identify DNA integration sites, such as insertional mutagenesis screens, gene and enhancer trap applications, and gene therapy. We...
8.
Varshney G, Pei W, LaFave M, Idol J, Xu L, Gallardo V, et al.
Genome Res
. 2015 Jun;
25(7):1030-42.
PMID: 26048245
The use of CRISPR/Cas9 as a genome-editing tool in various model organisms has radically changed targeted mutagenesis. Here, we present a high-throughput targeted mutagenesis pipeline using CRISPR/Cas9 technology in zebrafish...
9.
Yin L, Maddison L, Li M, Kara N, LaFave M, Varshney G, et al.
Genetics
. 2015 Apr;
200(2):431-41.
PMID: 25855067
Determining the mechanism of gene function is greatly enhanced using conditional mutagenesis. However, generating engineered conditional alleles is inefficient and has only been widely used in mice. Importantly, multiplex conditional...
10.
Quach H, Tao S, Vrljicak P, Joshi A, Ruan H, Sukumaran R, et al.
G3 (Bethesda)
. 2015 Apr;
5(6):1283-99.
PMID: 25840430
Since the sequencing of the human reference genome, many human disease-related genes have been discovered. However, understanding the functions of all the genes in the genome remains a challenge. The...