Matthew Batchelor
Overview
Explore the profile of Matthew Batchelor including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
165
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Recent Articles
1.
Rejnowicz E, Batchelor M, Leen E, Ahangar M, Burgess S, Richards M, et al.
Biochem J
. 2024 Oct;
481(21):1535-1556.
PMID: 39370942
Myc proteins are transcription factors crucial for cell proliferation. They have a C-terminal domain that mediates Max and DNA binding, and an N-terminal disordered region culminating in the transactivation domain...
2.
Holder J, Miles J, Batchelor M, Popple H, Walko M, Yeung W, et al.
EMBO J
. 2024 Sep;
43(22):5381-5420.
PMID: 39327527
Aurora-A is an essential cell-cycle kinase with critical roles in mitotic entry and spindle dynamics. These functions require binding partners such as CEP192 and TPX2, which modulate both kinase activity...
3.
Sandei I, Gaule T, Batchelor M, Paci E, Kim Y, Kulak A, et al.
Biomater Sci
. 2024 Aug;
12(20):5215-5224.
PMID: 39206560
A key factor in biomineralization is the use of organic molecules to direct the formation of inorganic materials. However, identification of molecules that can selectively produce the calcium carbonate polymorphs...
4.
Dawber R, Gimenez D, Batchelor M, Miles J, Wright M, Bayliss R, et al.
Chembiochem
. 2023 Oct;
25(2):e202300649.
PMID: 37907395
Using N-Myc as a starting template we showcase the systematic use of truncation and maleimide constraining to develop peptidomimetic inhibitors of the N-Myc/Aurora-A protein-protein interaction (PPI); a potential anticancer drug...
5.
Batchelor M, Dawber R, Wilson A, Bayliss R
Biochem J
. 2022 Feb;
479(5):687-700.
PMID: 35212726
How cellular functions are regulated through protein phosphorylation events that promote or inhibit protein-protein interactions (PPIs) is key to understanding regulatory molecular mechanisms. Whilst phosphorylation can orthosterically or allosterically influence...
6.
Tomlinson L, Batchelor M, Sarsby J, Byrne D, Brownridge P, Bayliss R, et al.
J Am Soc Mass Spectrom
. 2022 Jan;
33(3):420-435.
PMID: 35099954
Protein kinase inhibitors are highly effective in treating diseases driven by aberrant kinase signaling and as chemical tools to help dissect the cellular roles of kinase signaling complexes. Evaluating the...
7.
Batchelor M, Papachristos K, Stofella M, Yew Z, Paci E
Biochim Biophys Acta Gen Subj
. 2020 Apr;
1864(8):129613.
PMID: 32298790
Background: Single-molecule experimental techniques such as optical tweezers or atomic force microscopy are a direct probe of the mechanical unfolding/folding of individual proteins. They are also a means to investigate...
8.
Batchelor M, Wolny M, Baker E, Paci E, Kalverda A, Peckham M
J Biol Chem
. 2018 Dec;
294(9):3219-3234.
PMID: 30593502
Ion pairs are key stabilizing interactions between oppositely charged amino acid side chains in proteins. They are often depicted as single conformer salt bridges (hydrogen-bonded ion pairs) in crystal structures,...
9.
Batchelor M, Paci E
J Phys Chem B
. 2018 Oct;
122(49):11784-11791.
PMID: 30351106
Helices are the most common structural pattern observed in structured proteins. Polypeptide sequences that form helices in isolation have been identified and extensively studied. These are generally rich in alanine,...
10.
Batchelor M, Wolny M, Kurzawa M, Dougan L, Knight P, Peckham M
Methods Mol Biol
. 2018 Jul;
1805:185-211.
PMID: 29971719
Stable, single α-helical (SAH) domains exist in a number of unconventional myosin isoforms, as well as other proteins. These domains are formed from sequences rich in charged residues (Arg, Lys,...