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Matthew B Murphy

Explore the profile of Matthew B Murphy including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
11.
Bagheri M, Wang C, Shi M, Manouchehri A, Murray K, Murphy M, et al.
Sci Rep . 2021 Aug; 11(1):15652. PMID: 34341450
Inflammation increases the risk of cardiometabolic disease. Delineating specific inflammatory pathways and biomarkers of their activity could identify the mechanistic underpinnings of the increased risk. Plasma levels of kynurenine, a...
12.
Murphy M, Kumar P, Bradley A, Barton C, Deweese J, Mercer S
Bioorg Med Chem . 2020 Oct; 28(22):115773. PMID: 33035756
Etoposide is a widely-used anticancer agent that targets human type II topoisomerases. Evidence suggests that metabolism of etoposide in myeloid progenitor cells is associated with translocations involved in leukemia development....
13.
Prinsen J, Kannankeril P, Sidorova T, Yermalitskaya L, Boutaud O, Zagol-Ikapitte I, et al.
JACC Basic Transl Sci . 2020 Jul; 5(6):602-615. PMID: 32613146
Oxidative damage is implicated in atrial fibrillation (AF), but antioxidants are ineffective therapeutically. The authors tested the hypothesis that highly reactive lipid dicarbonyl metabolites, or isolevuglandins (IsoLGs), are principal drivers...
14.
Minardi S, Fernandez-Moure J, Fan D, Murphy M, Yazdi I, Liu X, et al.
Pharmaceutics . 2020 Feb; 12(2). PMID: 32024134
Bone morphogenetic protein-2 (BMP-2) has been demonstrated to be one of the most vital osteogenic factors for bone augmentation. However, its uncontrolled administration has been associated with catastrophic side effects,...
15.
Pettine K, Suzuki R, Sand T, Murphy M
Int Orthop . 2017 Jul; 41(10):2097-2103. PMID: 28748380
Purpose: The purpose of this study is to assess safety and feasibility of intradiscal bone marrow concentrate (BMC) injections to treat low back discogenic pain as an alternative to surgery...
16.
Anz A, Branch E, Rodriguez J, Chillemi F, Bruce J, Murphy M, et al.
Arthroscopy . 2017 Jan; 33(4):790-797. PMID: 28043750
Purpose: To examine the number of viable stem cells contained in the postinjury effusion fluid and the waste byproducts of arthroscopic cruciate ligament surgery. Methods: This study included patients older...
17.
Blashki D, Murphy M, Ferrari M, Simmons P, Tasciotti E
J Tissue Eng . 2016 Sep; 7:2041731416661196. PMID: 27579159
In this study, we show that matrix dense cortical bone is the more potent compartment of bone than bone marrow as a stromal source for mesenchymal stem cells as isolated...
18.
Murphy M, Suzuki R, Sand T, Chaput C, Gregory C
J Clin Med . 2015 Aug; 2(3):49-66. PMID: 26237062
For spinal fusions and the treatment of non-union fractures, biological substrates, scaffolds, or carriers often are applied as a graft to support regeneration of bone. The selection of an appropriate...
19.
Harrison R, Criss Z, Feller L, Modi S, Hardy J, Schmidt C, et al.
J Biomed Mater Res B Appl Biomater . 2015 Feb; 104(1):149-57. PMID: 25677680
Calcium phosphate-based cements with enhanced regenerative potential are promising biomaterials for the healing of bone defects in procedures such as percutaneous vertebroplasty. With a view to the use of such...
20.
Pettine K, Murphy M, Suzuki R, Sand T
Stem Cells . 2014 Sep; 33(1):146-56. PMID: 25187512
Degenerative disc disease (DDD) induces chronic back pain with limited nonsurgical options. In this open label pilot study, 26 patients (median age 40 years; range 18-61) received autologous bone marrow...