Matthew A Sleeman
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Explore the profile of Matthew A Sleeman including associated specialties, affiliations and a list of published articles.
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73
Citations
2268
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Recent Articles
1.
Wang B, Golubov J, Oswald E, Poon P, Wei Q, Lett C, et al.
EBioMedicine
. 2024 Sep;
108:105334.
PMID: 39270622
Background: Passive administration of SARS-CoV-2 neutralizing monoclonal antibodies (mAbs), such as CAS + IMD (Casirivimab + Imdevimab) antibody cocktail demonstrated beneficial effects on clinical outcomes in hospitalized patients with COVID-19...
2.
Vecchione A, Devlin J, Tasker C, Ramnarayan V, Haase P, Conde E, et al.
Sci Immunol
. 2024 Sep;
9(99):eadm8964.
PMID: 39241058
Understanding the phenotypic and transcriptional signature of immunoglobulin E (IgE)-producing cells is fundamental to plasma cell (PC) biology and development of therapeutic interventions for allergy. Here, using a mouse model...
3.
Limnander A, Kaur N, Asrat S, Tasker C, Boyapati A, Ben L, et al.
Sci Transl Med
. 2023 Dec;
15(726):eadf9561.
PMID: 38091405
Immunoglobulin E (IgE) is a key driver of type 1 hypersensitivity reactions and allergic disorders, which are globally increasing in number and severity. Although eliminating pathogenic IgE may be a...
4.
Asrat S, Devlin J, Vecchione A, Klotz B, Setliff I, Srivastava D, et al.
Cell Rep Methods
. 2023 Aug;
3(7):100522.
PMID: 37533642
Following activation by cognate antigen, B cells undergo fine-tuning of their antigen receptors and may ultimately differentiate into antibody-secreting cells (ASCs). While antigen-specific B cells that express surface receptors (B...
5.
Ebstein S, Rafique A, Zhou Y, Krasco A, Montalvo-Ortiz W, Yu L, et al.
Glycobiology
. 2023 Jun;
33(7):591-604.
PMID: 37341346
V-set and immunoglobulin domain-containing 4 (VSIG4) is a complement receptor of the immunoglobulin superfamily that is specifically expressed on tissue resident macrophages, and its many reported functions and binding partners...
6.
Koether K, Besnard V, Sandig H, Carruthers A, Miranda E, Grootenboer-Mignot S, et al.
Eur Respir J
. 2023 Apr;
61(5).
PMID: 37080573
Several reports have highlighted a potential role of autoreactive B-cells and autoantibodies that correlates with increased disease severity in patients with idiopathic pulmonary fibrosis (IPF). Here we show that patients...
7.
Le Floch A, Nagashima K, Birchard D, Scott G, Ben L, Ajithdoss D, et al.
Sci Transl Med
. 2023 Jan;
15(678):eabo0205.
PMID: 36630481
The common γ chain (γc; IL-2RG) is a subunit of the interleukin (IL) receptors for the γc cytokines IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. The lack of appropriate neutralizing...
8.
Scott G, Asrat S, Allinne J, Lim W, Nagashima K, Birchard D, et al.
Cytokine
. 2022 Dec;
162:156091.
PMID: 36481478
Rationale: Type 2 (T2) asthma is characterized by airflow limitations and elevated levels of blood and sputum eosinophils, fractional exhaled nitric oxide, IgE, and periostin. While eosinophils are associated with...
9.
Kwart D, He J, Srivatsan S, Lett C, Golubov J, Oswald E, et al.
Cell Rep
. 2022 Dec;
41(10):111769.
PMID: 36476866
Monocytes are highly plastic immune cells that modulate antitumor immunity. Therefore, identifying factors that regulate tumor monocyte functions is critical for developing effective immunotherapies. Here, we determine that endogenous cancer...
10.
Cable J, Saphire E, Hayday A, Wiltshire T, Mousa J, Humphreys D, et al.
Ann N Y Acad Sci
. 2022 Nov;
1519(1):153-166.
PMID: 36382536
Therapeutic antibodies have broad indications across diverse disease states, such as oncology, autoimmune diseases, and infectious diseases. New research continues to identify antibodies with therapeutic potential as well as methods...