Matthew A Horwitz
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Explore the profile of Matthew A Horwitz including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
91
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Recent Articles
1.
Campeau L, Horwitz M, Schultz D
Org Lett
. 2024 Jan;
26(14):2672-2676.
PMID: 38169530
No abstract available.
2.
Horwitz M, Durr A, Afratis K, Chen Z, Soika J, Christensen K, et al.
J Am Chem Soc
. 2023 Apr;
145(17):9708-9717.
PMID: 37079853
The controlled programming of regiochemical outcomes in nucleophilic fluorination reactions with alkali metal fluoride is a problem yet to be solved. Herein, two synergistic approaches exploiting hydrogen bonding catalysis are...
3.
Wang J, Horwitz M, Durr A, Ibba F, Pupo G, Gao Y, et al.
J Am Chem Soc
. 2022 Mar;
144(10):4572-4584.
PMID: 35230845
Asymmetric catalytic azidation has increased in importance to access enantioenriched nitrogen containing molecules, but methods that employ inexpensive sodium azide remain scarce. This encouraged us to undertake a detailed study...
4.
Fulton J, Horwitz M, Bruske E, Johnson J
J Org Chem
. 2020 Dec;
86(1):1308.
PMID: 33296209
No abstract available.
5.
Horwitz M, Robins J, Johnson J
J Org Chem
. 2020 May;
85(10):6808-6814.
PMID: 32352768
The synthesis of the stereotriad core in the eastern portion of the alkaloids jervine (), cyclopamine (), and veratramine () is reported. Starting from a known β-methyltyrosine derivative (), the...
6.
Cuadros S, Horwitz M, Schweitzer-Chaput B, Melchiorre P
Chem Sci
. 2019 Jul;
10(21):5484-5488.
PMID: 31293731
We report a photoinduced three-component radical process, which couples readily available alkyl chlorides, maleimides, and heteroaromatic fragments to rapidly generate complex chiral products with high diastereocontrol. This method generates radicals...
7.
Schweitzer-Chaput B, Horwitz M, de Pedro Beato E, Melchiorre P
Nat Chem
. 2018 Dec;
11(2):129-135.
PMID: 30510217
Chemists extensively use free radical reactivity for applications in organic synthesis, materials science, and life science. Traditionally, generating radicals requires strategies that exploit the bond dissociation energy or the redox...
8.
Fulton J, Horwitz M, Bruske E, Johnson J
J Org Chem
. 2018 Mar;
83(6):3385-3391.
PMID: 29512387
An asymmetric sulfa-Michael addition of alkyl thiols to enone diesters is reported. The reaction is catalyzed by a bifunctional triaryliminophosphorane-thiourea organocatalyst and provides a range of α-sulfaketones in high yields...
9.
Horwitz M, Fulton J, Johnson J
Org Lett
. 2017 Oct;
19(21):5783-5785.
PMID: 29035548
Enantio- and diastereoselective conjugate addition reactions between nitroethane or nitropropane and enone diesters are reported. A bifunctional triaryliminophosphorane catalyzed the addition reaction with consistently excellent stereoselectivities and yields across a...
10.
Horwitz M, Massolo E, Johnson J
Beilstein J Org Chem
. 2017 May;
13:762-767.
PMID: 28546832
We report a desymmetrization of cyclohexadienones by intramolecular conjugate addition of a tethered dithiane nucleophile. Mild reaction conditions allow the formation of diversely functionalized fused bicyclic lactones. The products participate...