Paolo Melchiorre
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Explore the profile of Paolo Melchiorre including associated specialties, affiliations and a list of published articles.
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Articles
107
Citations
1979
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Recent Articles
1.
Mallik S, Sfreddo E, Wang H, Melchiorre P
Chem Sci
. 2024 Nov;
16(1):124-129.
PMID: 39600514
4-Hydroxycoumarins are well-known for their ground-state nucleophilic behavior, which has been widely exploited for their functionalization. Herein, we reveal a previously unexplored photochemical reactivity: upon deprotonation and excitation with purple...
2.
Tseliou V, Kqiku L, Berger M, Schiel F, Zhou H, Poelarends G, et al.
Nature
. 2024 Sep;
634(8035):848-854.
PMID: 39255850
Photoenzymes are light-powered biocatalysts that typically rely on the excitation of cofactors or unnatural amino acids for their catalytic activities. A notable natural example is the fatty acid photodecarboxylase, which...
3.
Wu S, Melchiorre P
Angew Chem Int Ed Engl
. 2024 Jun;
63(37):e202407520.
PMID: 38887166
Thioesters are important in synthesis, materials science, and biology, and their preparation traditionally relies on the use of disagreeable thiols. Here, we report a thiol-free protocol that stitches together widespread...
4.
Wu S, Wong T, Righi P, Melchiorre P
J Am Chem Soc
. 2024 Jan;
146(5):2907-2912.
PMID: 38265336
Thioethers, often found in pharmaceuticals and natural compounds, typically involve metal cross-coupling reactions, high temperatures, and the use of disagreeable thiols for their synthesis. Here we present a straightforward, thiol-free...
5.
Zhou W, Dmitriev I, Melchiorre P
J Am Chem Soc
. 2023 Nov;
145(46):25098-25102.
PMID: 37947488
Olefins are widely available at low costs, which explains the usefulness of developing new methods for their functionalization. Here we report a simple protocol that uses a photoredox catalyst and...
6.
Wu S, Schiel F, Melchiorre P
Angew Chem Int Ed Engl
. 2023 Jun;
62(32):e202306364.
PMID: 37322860
Due to their strong covalent bonds and low reduction potentials, activating inert substrates is challenging. Recent advances in photoredox catalysis offered a number of solutions, each of which useful for...
7.
Balletti M, Wachsmuth T, Di Sabato A, Hartley W, Melchiorre P
Chem Sci
. 2023 May;
14(18):4923-4927.
PMID: 37181764
Herein, we report a photochemical organocatalytic method for the asymmetric introduction of perfluoroalkyl fragments (including the valuable trifluoromethyl moiety) at the remote γ-position of α-branched enals. The chemistry exploits the...
8.
Le Saux E, Georgiou E, Dmitriev I, Hartley W, Melchiorre P
J Am Chem Soc
. 2022 Dec;
145(1):47-52.
PMID: 36574031
We report a photochemical method for the functionalization of pyridines with radicals derived from allylic C-H bonds. Overall, two substrates undergo C-H functionalization to form a new C(sp)-C(sp) bond. The...
9.
Tseliou V, Faraone A, Kqiku L, Jan Vilim , Simionato G, Melchiorre P
Angew Chem Int Ed Engl
. 2022 Aug;
61(43):e202212176.
PMID: 36044588
Asymmetric catalytic cascade processes offer direct access to complex chiral molecules from simple substrates and in a single step. In biocatalysis, cascades are generally designed by combining multiple enzymes, each...
10.
Georgiou E, Spinnato D, Chen K, Melchiorre P, Muniz K
Chem Sci
. 2022 Aug;
13(27):8060-8064.
PMID: 35919417
We report a photocatalytic strategy for the chemodivergent radical benzylation of 4-cyanopyridines. The chemistry uses a single photoredox catalyst to generate benzyl radicals upon N-F bond activation of 2-alkyl -fluorobenzamides....