Matteo M E Metruccio
Overview
Explore the profile of Matteo M E Metruccio including associated specialties, affiliations and a list of published articles.
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18
Citations
389
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Recent Articles
1.
Datta A, Lee J, Flandrin O, Horneman H, Lee J, Metruccio M, et al.
Invest Ophthalmol Vis Sci
. 2023 Aug;
64(11):21.
PMID: 37585189
Purpose: Contact lens wear can induce corneal parainflammation involving CD11c+ cell responses (24 hours), γδ T cell responses (24 hours and 6 days), and IL-17-dependent Ly6G+ cell responses (6 days)....
2.
Wan S, Datta A, Flandrin O, Metruccio M, Ma S, Nieto V, et al.
FASEB J
. 2021 Sep;
35(10):e21899.
PMID: 34569661
The cornea of the eye differs from other mucosal surfaces in that it lacks a viable bacterial microbiome and by its unusually high density of sensory nerve endings. Here, we...
3.
Fleiszig S, Kroken A, Nieto V, Grosser M, Wan S, Metruccio M, et al.
Prog Retin Eye Res
. 2019 Nov;
76:100804.
PMID: 31756497
Contact lenses represent a widely utilized form of vision correction with more than 140 million wearers worldwide. Although generally well-tolerated, contact lenses can cause corneal infection (microbial keratitis), with an...
4.
Li J, Wan S, Metruccio M, Ma S, Nazmi K, Bikker F, et al.
Sci Rep
. 2019 Sep;
9(1):13146.
PMID: 31511582
The scavenging capacity of glycoprotein DMBT1 helps defend mucosal epithelia against microbes. DMBT1 binding to multiple bacterial species involves its conserved Scavenger Receptor Cysteine-Rich (SRCR) domains, localized to a 16-mer...
5.
Nieto V, Kroken A, Grosser M, Smith B, Metruccio M, Hagan P, et al.
mBio
. 2019 Aug;
10(4).
PMID: 31431558
is among bacterial pathogens capable of twitching motility, a form of surface-associated movement dependent on type IV pili (T4P). Previously, we showed that T4P and twitching were required for to...
6.
Metruccio M, Wan S, Horneman H, Kroken A, Sullivan A, Truong T, et al.
Ocul Surf
. 2018 Nov;
17(1):119-133.
PMID: 30439473
Purpose: Contact lens wear carries a risk of complications, including corneal infection. Solving these complications has been hindered by limitations of existing animal models. Here, we report development of a...
7.
Wan S, Sullivan A, Shieh P, Metruccio M, Evans D, Bertozzi C, et al.
Front Microbiol
. 2018 Jun;
9:1117.
PMID: 29896179
Microbial communities are important for the health of mucosal tissues. Traditional culture and gene sequencing have demonstrated bacterial populations on the conjunctiva. However, it remains unclear if the cornea, a...
8.
Metruccio M, Tam C, Evans D, Xie A, Stern M, Fleiszig S
Sci Rep
. 2017 Oct;
7(1):13829.
PMID: 29062042
Previously we reported that corneal epithelial barrier function against Pseudomonas aeruginosa was MyD88-dependent. Here, we explored contributions of MyD88-dependent receptors using vital mouse eyes and confocal imaging. Uninjured IL-1R (-/-)...
9.
Li J, Metruccio M, Smith B, Evans D, Fleiszig S
PLoS Pathog
. 2017 Sep;
13(9):e1006612.
PMID: 28898291
[This corrects the article DOI: 10.1371/journal.ppat.1006392.].
10.
Li J, Metruccio M, Evans D, Fleiszig S
PLoS Pathog
. 2017 May;
13(5):e1006392.
PMID: 28489917
It is generally thought that mucosal fluids protect underlying epithelial surfaces against opportunistic infection via their antimicrobial activity. However, our published data show that human tear fluid can protect against...