Matt Pennell
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Explore the profile of Matt Pennell including associated specialties, affiliations and a list of published articles.
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24
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62
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Recent Articles
1.
Cope A, Schraiber J, Pennell M
Science
. 2025 Mar;
387(6738):1063-1068.
PMID: 40048509
The regulation of messenger RNA (mRNA) and protein abundances is well-studied, but less is known about the evolutionary processes shaping their relationship. To address this, we derived a new phylogenetic...
2.
Pennell M, MacPherson A
Philos Trans R Soc Lond B Biol Sci
. 2025 Feb;
380(1919):20230299.
PMID: 39976403
Yule's 1925 paper introducing the branching model that bears his name was a landmark contribution to the biodiversity sciences. In his paper, Yule developed stochastic models to explain the observed...
3.
Voss K, Kaur K, Banerjee R, Breden F, Pennell M
Front Immunol
. 2024 Dec;
15:1505032.
PMID: 39687606
The adaptive immune system generates a diverse array of B-cell receptors through the processes of V(D)J recombination and somatic hypermutation. B-cell receptors that bind to an antigen will undergo clonal...
4.
Jiang D, Pennell M
bioRxiv
. 2024 Dec;
PMID: 39677663
Explaining macroevolutionary divergence in light of population genetics requires understanding the extent to which the patterns of mutational input contribute to long-term trends. In the context of quantitative traits, mutational...
5.
Schraiber J, Edge M, Pennell M
PLoS Biol
. 2024 Oct;
22(10):e3002847.
PMID: 39383205
In both statistical genetics and phylogenetics, a major goal is to identify correlations between genetic loci or other aspects of the phenotype or environment and a focal trait. In these...
6.
Yoo D, Rhie A, Hebbar P, Antonacci F, Logsdon G, Solar S, et al.
bioRxiv
. 2024 Aug;
PMID: 39131277
We present haplotype-resolved reference genomes and comparative analyses of six ape species, namely: chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan, and siamang. We achieve chromosome-level contiguity with unparalleled sequence accuracy...
7.
Kalbfleisch T, McKay S, Murdoch B, Adelson D, Almansa-Villa D, Becker G, et al.
Nat Genet
. 2024 Aug;
56(8):1566-1573.
PMID: 39103649
Telomere-to-telomere (T2T) assemblies reveal new insights into the structure and function of the previously 'invisible' parts of the genome and allow comparative analyses of complete genomes across entire clades. We...
8.
David K, Schraiber J, Crandall J, Labella A, Opulente D, Harrison M, et al.
bioRxiv
. 2024 Aug;
PMID: 39091791
Many remarkable innovations have repeatedly occurred across vast evolutionary distances. When convergent traits emerge on the tree of life, they are sometimes driven by the same underlying gene families, while...
9.
Zhu Y, Watson C, Safonova Y, Pennell M, Bankevich A
bioRxiv
. 2024 Aug;
PMID: 39091785
Long-read sequencing technologies have revolutionized genome assembly producing near-complete chromosome assemblies for numerous organisms, which are invaluable to research in many fields. However, regions with complex repetitive structure continue to...
10.
Jiang D, Kejiou N, Qiu Y, Palazzo A, Pennell M
bioRxiv
. 2024 Aug;
PMID: 39091777
RNA and protein expressed from the same gene can have diverse isoforms due to various post-transcriptional and post-translational modifications. For the vast majority of alternative isoforms, It is unknown whether...