Chris Todd Hittinger
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Explore the profile of Chris Todd Hittinger including associated specialties, affiliations and a list of published articles.
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123
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3947
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Recent Articles
1.
Lee S, West C, Opulente D, Harrison M, Wolters J, Shen X, et al.
bioRxiv
. 2025 Mar;
PMID: 40060456
The Saccharomycotina fungi have evolved to inhabit a vast diversity of habitats over their 400-million-year evolution. There are, however, only a few known fungal pathogens of plants in this subphylum,...
2.
Barten L, Crandall J, Xie D, Serate J, Handowski E, Jen A, et al.
bioRxiv
. 2025 Jan;
PMID: 39829844
Biofuels derived from renewable and sustainable lignocellulosic biomass, such as switchgrass, offer a promising means to limit greenhouse gas emissions. However, switchgrass grown under drought conditions contains high levels of...
3.
Crandall J, Zhou X, Rokas A, Hittinger C
Mol Biol Evol
. 2024 Nov;
41(11).
PMID: 39492761
Functional innovation at the protein level is a key source of evolutionary novelties. The constraints on functional innovations are likely to be highly specific in different proteins, which are shaped...
4.
Rojas J, Hose J, Dutcher H, Place M, Wolters J, Hittinger C, et al.
Cell Genom
. 2024 Sep;
4(10):100656.
PMID: 39317188
Although implicated as deleterious in many organisms, aneuploidy can underlie rapid phenotypic evolution. However, aneuploidy will be maintained only if the benefit outweighs the cost, which remains incompletely understood. To...
5.
Goncalves C, Harrison M, Steenwyk J, Opulente D, LaBella A, Wolters J, et al.
PLoS Biol
. 2024 Sep;
22(9):e3002832.
PMID: 39312572
Many distantly related organisms have convergently evolved traits and lifestyles that enable them to live in similar ecological environments. However, the extent of phenotypic convergence evolving through the same or...
6.
Harrison M, Opulente D, Wolters J, Shen X, Zhou X, Groenewald M, et al.
Yeast
. 2024 Sep;
41(10):615-628.
PMID: 39295298
Yeasts in the subphylum Saccharomycotina are found across the globe in disparate ecosystems. A major aim of yeast research is to understand the diversity and evolution of ecological traits, such...
7.
Zavala B, Dineen L, Fisher K, Opulente D, Harrison M, Wolters J, et al.
G3 (Bethesda)
. 2024 Aug;
14(11).
PMID: 39213398
Codon usage bias, or the unequal use of synonymous codons, is observed across genes, genomes, and between species. It has been implicated in many cellular functions, such as translation dynamics...
8.
Crandall J, Zhou X, Rokas A, Hittinger C
bioRxiv
. 2024 Aug;
PMID: 39091816
Functional innovation at the protein level is a key source of evolutionary novelties. The constraints on functional innovations are likely to be highly specific in different proteins, which are shaped...
9.
David K, Schraiber J, Crandall J, Labella A, Opulente D, Harrison M, et al.
bioRxiv
. 2024 Aug;
PMID: 39091791
Many remarkable innovations have repeatedly occurred across vast evolutionary distances. When convergent traits emerge on the tree of life, they are sometimes driven by the same underlying gene families, while...
10.
Liu C, Zhou X, Li Y, Hittinger C, Pan R, Huang J, et al.
Syst Biol
. 2024 Jun;
73(5):807-822.
PMID: 38940001
Maximum likelihood (ML) phylogenetic inference is widely used in phylogenomics. As heuristic searches most likely find suboptimal trees, it is recommended to conduct multiple (e.g., 10) tree searches in phylogenetic...