Mathilde H Lerche
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Explore the profile of Mathilde H Lerche including associated specialties, affiliations and a list of published articles.
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34
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2084
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Recent Articles
1.
Christensen N, Holm R, Sanchez J, Hansen E, Lerche M, Ardenkjaer-Larsen J, et al.
NMR Biomed
. 2024 Jan;
37(5):e5107.
PMID: 38279190
Hyperpolarized carbon-13 labeled compounds are increasingly being used in medical MR imaging (MRI) and MR imaging (MRI) and spectroscopy (MRS) research, due to its ability to monitor tissue and cell...
2.
Capozzi A, Kilund J, Karlsson M, Patel S, Pinon A, Vibert F, et al.
Commun Chem
. 2023 Jan;
4(1):95.
PMID: 36697707
Magnetic Resonance Imaging combined with hyperpolarized C-labelled metabolic contrast agents produced via dissolution Dynamic Nuclear Polarization can, non-invasively and in real-time, report on tissue specific aberrant metabolism. However, hyperpolarization equipment...
3.
Malinowski R, Ghiasi S, Mandrup-Poulsen T, Meier S, Lerche M, Ardenkjaer-Larsen J, et al.
Sci Rep
. 2020 Sep;
10(1):15413.
PMID: 32963286
Pancreatic β-cells become irreversibly damaged by long-term exposure to excessive glucose concentrations and lose their ability to carry out glucose stimulated insulin secretion (GSIS) upon damage. The β-cells are not...
4.
Kampmeyer C, Johansen J, Holmberg C, Karlson M, Gersing S, Bordallo H, et al.
ACS Synth Biol
. 2020 Mar;
9(4):733-748.
PMID: 32142608
Life is completely dependent on water. To analyze the role of water as a solvent in biology, we replaced water with heavy water (DO) and investigated the biological effects by...
5.
Yoshihara H, Bastiaansen J, Karlsson M, Lerche M, Comment A, Schwitter J
NMR Biomed
. 2020 Jan;
33(3):e4243.
PMID: 31904900
Under normal conditions, the heart mainly relies on fatty acid oxidation to meet its energy needs. Changes in myocardial fuel preference are noted in the diseased and failing heart. The...
6.
Lerche M, Karlsson M, Ardenkjaer-Larsen J, Jensen P
Methods Mol Biol
. 2019 Aug;
2037:385-393.
PMID: 31463856
Metabolite profiles and their isotopomer distributions can be studied noninvasively in complex mixtures with NMR. The advent of hyperpolarized C-NMR using quantitative dissolution Dynamic Nuclear Polarization (qdDNP) and isotope enrichment...
7.
Capozzi A, Patel S, Wenckebach W, Karlsson M, Lerche M, Ardenkjaer-Larsen J
J Phys Chem Lett
. 2019 Jun;
10(12):3420-3425.
PMID: 31181932
We show that the trityl electron spin resonance (ESR) features, crucial for an efficient dynamic nuclear polarization (DNP) process, are sample-composition-dependent. Working at 6.7 T and 1.1 K with a...
8.
Capozzi A, Patel S, Gunnarsson C, Marco-Rius I, Comment A, Karlsson M, et al.
Angew Chem Int Ed Engl
. 2019 Apr;
58(19):6126.
PMID: 31017376
No abstract available.
9.
Capozzi A, Patel S, Gunnarsson C, Marco-Rius I, Comment A, Karlsson M, et al.
Angew Chem Int Ed Engl
. 2018 Dec;
58(5):1334-1339.
PMID: 30515929
Free radicals generated by UV-light irradiation of a frozen solution containing a fraction of pyruvic acid (PA) have demonstrated their dissolution dynamic nuclear polarization (dDNP) potential, providing up to 30 ...
10.
Zhang G, Ahola S, Lerche M, Telkki V, Hilty C
Anal Chem
. 2018 Aug;
90(18):11131-11137.
PMID: 30125087
Ultrafast Laplace NMR (UF-LNMR), which is based on the spatial encoding of multidimensional data, enables one to carry out 2D relaxation and diffusion measurements in a single scan. Besides reducing...