Mathieu N Flamand
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Explore the profile of Mathieu N Flamand including associated specialties, affiliations and a list of published articles.
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13
Citations
306
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Recent Articles
1.
Flamand M, Meyer K
Methods Enzymol
. 2024 Oct;
705:127-157.
PMID: 39389662
RNA-binding proteins (RBPs) are central players in RNA homeostasis and the control of gene expression. The identification of RBP targets, interactions, and the regulatory networks they control is crucial for...
2.
Flamand M, Tegowski M, Meyer K
Annu Rev Biochem
. 2023 Apr;
92:145-173.
PMID: 37068770
Over the past decade, mRNA modifications have emerged as important regulators of gene expression control in cells. Fueled in large part by the development of tools for detecting RNA modifications...
3.
Flamand M, Ke K, Tamming R, Meyer K
Genes Dev
. 2022 Oct;
36(17-18):1002-1015.
PMID: 36302554
RNA-binding proteins (RBPs) regulate nearly every aspect of mRNA processing and are important regulators of gene expression in cells. However, current methods for transcriptome-wide identification of RBP targets are limited,...
4.
Choi S, Flamand M, Liu B, Zhu H, Hu M, Wang M, et al.
Cell Rep
. 2022 Aug;
40(9):111293.
PMID: 36044854
N-methyladenosine (mA) is deposited co-transcriptionally on thousands of cellular mRNAs and plays important roles in mRNA processing and cellular function. mA is particularly abundant within the brain and is critical...
5.
Flamand M, Meyer K
Nucleic Acids Res
. 2022 Apr;
50(8):4464-4483.
PMID: 35438793
The transport of mRNAs to distal subcellular compartments is an important component of spatial gene expression control in neurons. However, the mechanisms that control mRNA localization in neurons are not...
6.
Tegowski M, Flamand M, Meyer K
Mol Cell
. 2022 Jan;
82(4):868-878.e10.
PMID: 35081365
N-methyladenosine (mA) is an abundant RNA modification that plays critical roles in RNA regulation and cellular function. Global mA profiling has revealed important aspects of mA distribution and function, but...
7.
Mayya V, Flamand M, Lambert A, Jafarnejad S, Wohlschlegel J, Sonenberg N, et al.
Nucleic Acids Res
. 2021 Mar;
49(9):4803-4815.
PMID: 33758928
microRNA (miRNA)-mediated gene silencing is enacted through the recruitment of effector proteins that direct translational repression or degradation of mRNA targets, but the relative importance of their activities for animal...
8.
Lewis A, Berkyurek A, Greiner A, Sawh A, Vashisht A, Merrett S, et al.
Mol Cell
. 2020 Apr;
78(5):862-875.e8.
PMID: 32348780
Nuclear RNA interference (RNAi) pathways work together with histone modifications to regulate gene expression and enact an adaptive response to transposable RNA elements. In the germline, nuclear RNAi can lead...
9.
Flamand M, Meyer K
Curr Opin Neurobiol
. 2019 May;
59:41-48.
PMID: 31108373
RNA modifications, collectively referred to as 'the epitranscriptome,' have recently emerged as a pervasive feature of cellular mRNAs which have diverse impacts on gene expression. In the last several years,...
10.
Tran A, Chapman E, Flamand M, Yu B, Krempel S, Duchaine T, et al.
Cell Death Differ
. 2019 Apr;
26(12):2637-2651.
PMID: 30952991
Apoptosis is a genetically programmed cell death process with profound roles in development and disease. MicroRNAs modulate the expression of many proteins and are often deregulated in human diseases, such...