Mathias Winterhalter
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Explore the profile of Mathias Winterhalter including associated specialties, affiliations and a list of published articles.
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183
Citations
3477
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Recent Articles
11.
Bodrenko I, Zewdie T, Wang J, Paul E, Witt S, Winterhalter M
Biochimie
. 2023 Jan;
205:102-109.
PMID: 36646205
Characterizing protein-protein interaction on a single molecular level is a challenge, experimentally as well as interpretation of the data. For example, Gram-negative bacteria contain protein complexes spanning the outer and...
12.
Acharya A, Ghai I, Piselli C, Prajapati J, Benz R, Winterhalter M, et al.
J Chem Inf Model
. 2022 Dec;
63(3):910-927.
PMID: 36525563
In the present work, we delineate the molecular mechanism of a bulky antibiotic permeating through a bacterial channel and uncover the role of conformational dynamics of the constriction loop in...
13.
Masi M, Vergalli J, Ghai I, Barba-Bon A, Schembri T, Nau W, et al.
Commun Biol
. 2022 Oct;
5(1):1059.
PMID: 36198902
Gram-negative porins are the main entry for small hydrophilic molecules. We studied translocation of structurally related cephalosporins, ceftazidime (CAZ), cefotaxime (CTX) and cefepime (FEP). CAZ is highly active on E....
14.
Wang J, Prajapati J, Gao F, Ying Y, Kleinekathofer U, Winterhalter M, et al.
J Am Chem Soc
. 2022 Aug;
144(33):15072-15078.
PMID: 35953064
Chirality is essential in nearly all biological organizations and chemical reactions but is rarely considered due to technical limitations in identifying L/D isomerization. Using OmpF, a membrane channel from with...
15.
Farci D, Haniewicz P, de Sanctis D, Iesu L, Kereiche S, Winterhalter M, et al.
J Biol Chem
. 2022 May;
298(6):102031.
PMID: 35577074
The radiation-resistant bacterium Deinococcus radiodurans is known as the world's toughest bacterium. The S-layer of D. radiodurans, consisting of several proteins on the surface of the cellular envelope and intimately...
16.
Prajapati J, Pangeni S, Aksoyoglu M, Winterhalter M, Kleinekathofer U
ACS Nano
. 2022 Apr;
16(5):7701-7712.
PMID: 35435659
The voltage-dependent transport through biological and artificial nanopores is being used in many applications such as DNA or protein sequencing and sensing. The primary approach to determine the transport has...
17.
Ahmed T, Bafna J, Hemmler R, Gall K, Wagner R, Winterhalter M, et al.
Membranes (Basel)
. 2022 Mar;
12(3).
PMID: 35323784
In this work, we present a microsystem setup for performing sensitive biological membrane translocation measurements. Thin free-standing synthetic bilayer lipid membranes (BLM) were constructed in microfabricated silicon nitride apertures (<100...
18.
Arisetti N, Fuchs H, Coetzee J, Orozco M, Ruppelt D, Bauer A, et al.
Chem Sci
. 2022 Jan;
12(48):16023-16034.
PMID: 35024125
Emerging antimicrobial resistance urges the discovery of antibiotics with unexplored, resistance-breaking mechanisms. Armeniaspirols represent a novel class of antibiotics with a unique spiro[4.4]non-8-ene scaffold and potent activities against Gram-positive pathogens....
19.
The C2 entity of chitosugars is crucial in molecular selectivity of the Vibrio campbellii chitoporin
Suginta W, Sanram S, Aunkham A, Winterhalter M, Schulte A
J Biol Chem
. 2021 Oct;
297(6):101350.
PMID: 34715124
The marine bacterium Vibrio campbellii expresses a chitooligosaccharide-specific outer-membrane channel (chitoporin) for the efficient uptake of nutritional chitosugars that are externally produced through enzymic degradation of environmental host shell chitin....
20.
Sadeghi S, Deshpande S, Vallerinteavide Mavelli G, Aksoyoglu A, Bafna J, Winterhalter M, et al.
Nat Commun
. 2021 Sep;
12(1):5720.
PMID: 34588451
In vitro protein folding is a complex process which often results in protein aggregation, low yields and low specific activity. Here we report the use of nanoscale exoshells (tES) to...