Jayesh Arun Bafna
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Explore the profile of Jayesh Arun Bafna including associated specialties, affiliations and a list of published articles.
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10
Citations
84
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Recent Articles
1.
Ahmed T, Bafna J, Hemmler R, Gall K, Wagner R, Winterhalter M, et al.
Membranes (Basel)
. 2022 Mar;
12(3).
PMID: 35323784
In this work, we present a microsystem setup for performing sensitive biological membrane translocation measurements. Thin free-standing synthetic bilayer lipid membranes (BLM) were constructed in microfabricated silicon nitride apertures (<100...
2.
Ozturk Y, Ebrahimi A, Norouz Dizaji A, Kaygusuz O, Bafna J, Winterhalter M, et al.
Biomed Microdevices
. 2021 Feb;
23(1):12.
PMID: 33638734
Free standing artificial lipid bilayers are widely used in the study of biological pores. In these types of studies, the free standing planar lipid bilayer is formed over a micron-sized...
3.
Bafna J, Sans-Serramitjana E, Acosta-Gutierrez S, Bodrenko I, Horompoli D, Berscheid A, et al.
ACS Infect Dis
. 2020 May;
6(7):1855-1865.
PMID: 32369342
Despite decades of therapeutic application of aminoglycosides, it is still a matter of debate if porins contribute to the translocation of the antibiotics across the bacterial outer membrane. Here, we...
4.
Ahmed T, van den Driesche S, Bafna J, Oellers M, Hemmler R, Gall K, et al.
Biomed Microdevices
. 2020 May;
22(2):32.
PMID: 32355998
We present a chip design allowing rapid and robust lipid bilayer (LBL) membrane formation using a Parylene coated thin silicon nitride aperture. After bilayer formation, single membrane channels can be...
5.
Farci D, Aksoyoglu M, Farci S, Bafna J, Bodrenko I, Ceccarelli M, et al.
J Biol Chem
. 2020 Feb;
295(13):4224-4236.
PMID: 32071085
In the extremophile bacterium , the outermost surface layer is tightly connected with the rest of the cell wall. This integrated organization provides a compact structure that shields the bacterium...
6.
Wang J, Terrasse R, Bafna J, Benier L, Winterhalter M
Angew Chem Int Ed Engl
. 2020 Feb;
59(22):8517-8521.
PMID: 32023354
Multi-drug resistance in Gram-negative bacteria is often associated with low permeability of the outer membrane. To investigate the role of membrane channels in the uptake of antibiotics, we present an...
7.
Schmitt C, Bafna J, Schmid B, Klingl S, Baier S, Hemmis B, et al.
Biochim Biophys Acta Biomembr
. 2019 Jul;
1861(10):183021.
PMID: 31306626
OmpG is a general diffusion pore in the E. coli outer membrane with a molecular architecture comprising a 14-stranded β-barrel scaffold and unique structural features. In contrast to other non-specific...
8.
Wang J, Bafna J, Bhamidimarri S, Winterhalter M
Angew Chem Int Ed Engl
. 2019 Feb;
58(14):4737-4741.
PMID: 30701680
Biological channels facilitate the exchange of molecules across membranes, but general tools to quantify transport are missing. Electrophysiology is the method of choice to study the functional properties of channels....
9.
Golla V, Sans-Serramitjana E, Pothula K, Benier L, Bafna J, Winterhalter M, et al.
Biophys J
. 2019 Jan;
116(2):258-269.
PMID: 30616836
Fosfomycin is a frequently prescribed drug in the treatment of acute urinary tract infections. It enters the bacterial cytoplasm and inhibits the biosynthesis of peptidoglycans by targeting the MurA enzyme....
10.
Ghai I, Bajaj H, Bafna J, El Damrany Hussein H, Winterhalter M, Wagner R
J Biol Chem
. 2018 Mar;
293(18):7030-7037.
PMID: 29540483
The outer cell wall of the Gram-negative bacteria is a crucial barrier for antibiotics to reach their target. Here, we show that the chemical stability of the widely used antibiotic...