Mathea S Galanski
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Explore the profile of Mathea S Galanski including associated specialties, affiliations and a list of published articles.
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37
Citations
446
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Recent Articles
1.
Maier T, Wutschitz J, Gajic N, Hejl M, Cseh K, Mai S, et al.
Dalton Trans
. 2023 Oct;
52(44):16326-16335.
PMID: 37855721
The reaction of (1,2)-(cyclohexane-1,2-diamine)dichloridoplatinum(II) with maleic acid unexpectedly resulted in the formation of an organometallic platinum(II) complex featuring a ,-coordinating ligand. Additionally, a small series of close derivatives with increasing...
2.
Lerchbammer-Kreith Y, Hejl M, Sommerfeld N, Weng-Jiang X, Odunze U, Mellor R, et al.
Pharmaceuticals (Basel)
. 2023 Jul;
16(7).
PMID: 37513938
Quaternary ammonium palmitoyl glycol chitosan (GCPQ) has already shown beneficial drug delivery properties and has been studied as a carrier for anticancer agents. Consequently, we synthesised cytotoxic platinum(IV) conjugates of...
3.
Lerchbammer-Kreith Y, Hejl M, Vician P, Jakupec M, Berger W, Galanski M, et al.
Pharmaceutics
. 2023 May;
15(5).
PMID: 37242758
Based on their drug delivery properties and activity against tumors, we combined PAMAM dendrimers with various platinum(IV) complexes in order to provide an improved approach of anticancer treatment. Platinum(IV) complexes...
4.
Lerchbammer-Kreith Y, Sommerfeld N, Cseh K, Weng-Jiang X, Odunze U, Schatzlein A, et al.
Pharmaceutics
. 2023 Apr;
15(4).
PMID: 37111536
A new class of anticancer prodrugs was designed by combining the cytotoxicity of platinum(IV) complexes and the drug carrier properties of glycol chitosan polymers: Unsymmetrically carboxylated platinum(IV) analogues of cisplatin,...
5.
Legin A, Schintlmeister A, Sommerfeld N, Eckhard M, Theiner S, Reipert S, et al.
Nanoscale Adv
. 2022 Sep;
3(1):249-262.
PMID: 36131874
Oxaliplatin shows a superior clinical activity in colorectal cancer compared to cisplatin. Nevertheless, the knowledge about its cellular distribution and the mechanisms responsible for the different range of oxaliplatin-responsive tumors...
6.
Legin A, Schintlmeister A, Jakupec M, Galanski M, Lichtscheidl I, Wagner M, et al.
Chem Sci
. 2022 Aug;
5(8):3135-3143.
PMID: 35919909
Multi-elemental, isotope selective nano-scale secondary ion mass spectrometry (NanoSIMS) combined with confocal laser-scanning microscopy was used to characterize the subcellular distribution of N-labeled cisplatin in human colon cancer cells. These...
7.
Harringer S, Hejl M, Enyedy E, Jakupec M, Galanski M, Keppler B, et al.
Dalton Trans
. 2021 May;
50(23):8167-8178.
PMID: 34031671
The synergistic combination of the anticancer drug carboplatin and the iron chelator deferoxamine (DFO) served as a foundation for the development of novel multifunctional prodrugs. Hence, five platinum(iv) complexes, featuring...
8.
Theiner S, Grabarics M, Galvez L, Varbanov H, Sommerfeld N, Galanski M, et al.
Dalton Trans
. 2018 Mar;
47(15):5252-5258.
PMID: 29560976
The potential advantage of platinum(iv) complexes as alternatives to classical platinum(ii)-based drugs relies on their kinetic stability in the body before reaching the tumor site and on their activation by...
9.
Hofer D, Varbanov H, Hejl M, Jakupec M, Roller A, Galanski M, et al.
J Inorg Biochem
. 2017 Jul;
174:119-129.
PMID: 28666155
The impact of the equatorial coordination sphere on the reduction behavior (i.e. rate of reduction) of platinum(IV) complexes with axial carboxylato ligands was studied. Moreover, the influence of equatorial ligands...
10.
Varbanov H, Ortiz D, Hofer D, Menin L, Galanski M, Keppler B, et al.
Dalton Trans
. 2017 Jun;
46(28):8929-8932.
PMID: 28654098
Herein we show that oxaliplatin reacts rapidly with DMSO in aqueous solutions, despite being stable in pure DMSO and pure water. Furthermore, the reactivity of the clinically applied Pt(ii) drugs...