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Massimo Masiero

Explore the profile of Massimo Masiero including associated specialties, affiliations and a list of published articles. Areas
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Articles 17
Citations 610
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Recent Articles
11.
Whiteman P, Hernandez de Madrid B, Taylor P, Li D, Heslop R, Viticheep N, et al.
J Biol Chem . 2013 Jan; 288(10):7305-12. PMID: 23339193
We have mapped a Jagged/Serrate-binding site to specific residues within the 12th EGF domain of human and Drosophila Notch. Two critical residues, involved in a hydrophobic interaction, provide a ligand-binding...
12.
Serafin V, Persano L, Moserle L, Esposito G, Ghisi M, Curtarello M, et al.
J Pathol . 2011 May; 224(4):448-60. PMID: 21598247
Increased Notch1 activity has been observed in intestinal tumours, partially accomplished by β-catenin-mediated up-regulation of the Notch ligand Jagged-1. Whether further mechanisms of Notch activation exist and other Notch receptors...
13.
Indraccolo S, Minuzzo S, Masiero M, Amadori A
Cell Cycle . 2009 Dec; 9(1):80-5. PMID: 20016278
The Notch pathway is an evolutionally conserved cell-cell interaction signalling system involved in several key aspects of cell life, ranging from differentiation and proliferation to apoptosis. As such, it plays...
14.
Indraccolo S, Minuzzo S, Masiero M, Pusceddu I, Persano L, Moserle L, et al.
Cancer Res . 2009 Feb; 69(4):1314-23. PMID: 19208840
The Notch ligand Dll4 has a recognized role during both physiologic and tumor angiogenesis, as it contributes to regulate Notch activity in endothelial cells (EC). The effects of Dll4 on...
15.
Favaro E, Nardo G, Persano L, Masiero M, Moserle L, Zamarchi R, et al.
Am J Pathol . 2008 Sep; 173(4):1186-201. PMID: 18772337
Hypoxia and the acquisition of a glycolytic phenotype are intrinsic features of the tumor microenvironment. The hypoxia inducible factor-1alpha (HIF-1alpha) pathway is activated under hypoxic conditions and orchestrates a complex...
16.
Piovan E, Tosello V, Indraccolo S, Masiero M, Persano L, Esposito G, et al.
Cancer Res . 2007 Sep; 67(18):8605-14. PMID: 17875700
The chemokine receptor CXCR4 plays a central role in organ-specific homing and tumor spreading and is induced by hypoxia. B lymphocytes are exposed to low oxygen tensions during their development,...
17.
Masiero M, Nardo G, Indraccolo S, Favaro E
Mol Aspects Med . 2007 Feb; 28(1):143-66. PMID: 17307250
RNA interference (RNAi) has emerged as one of the most important discoveries of the last years in the field of molecular biology. Following clarification of this highly conserved endogenous gene...