Massimiliano Porrini
Overview
Explore the profile of Massimiliano Porrini including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
228
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0
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Recent Articles
1.
Abi-Ghanem J, Rabin C, Porrini M, Rosu F, Gabelica V
J Am Soc Mass Spectrom
. 2020 Aug;
31(10):2035-2043.
PMID: 32812759
When electrosprayed from typical native MS solution conditions, RNA hairpins and kissing complexes acquire charge states at which they get significantly more compact in the gas phase than their initial...
2.
Daly S, Porrini M, Rosu F, Gabelica V
Faraday Discuss
. 2019 Apr;
217(0):361-382.
PMID: 31033983
In solution, UV-vis spectroscopy is often used to investigate structural changes in biomolecules (e.g., nucleic acids), owing to changes in the environment of their chromophores (e.g., the nucleobases). Here we...
3.
Abi-Ghanem J, Rabin C, Porrini M, Dausse E, Toulme J, Gabelica V
Chemphyschem
. 2017 Aug;
18(19):2782-2790.
PMID: 28762245
In the RNA realm, non-Watson-Crick base pairs are abundant and can affect both the RNA 3D structure and its function. Here, we investigated the formation of RNA kissing complexes in...
4.
Porrini M, Rosu F, Rabin C, Darre L, Gomez H, Orozco M, et al.
ACS Cent Sci
. 2017 Jun;
3(5):454-461.
PMID: 28573208
We report on the fate of nucleic acids conformation in the gas phase as sampled using native mass spectrometry coupled to ion mobility spectrometry. On the basis of several successful...
5.
Pacholarz K, Burnley R, Jowitt T, Ordsmith V, Pisco J, Porrini M, et al.
Structure
. 2017 Apr;
25(5):730-738.e4.
PMID: 28392260
MtATP-phosphoribosyltransferase (MtATP-PRT) is an enzyme catalyzing the first step of the biosynthesis of L-histidine in Mycobacterium tuberculosis, and proposed to be regulated via an allosteric mechanism. Native mass spectrometry (MS)...
6.
Cole H, Porrini M, Morris R, Smith T, Kalapothakis J, Weidt S, et al.
Analyst
. 2015 Sep;
140(20):7000-11.
PMID: 26369607
A prevalent type of protein misfolding causes the formation of β-sheet-rich structures known as amyloid fibrils. Research into the mechanisms of fibril formation has implications for both disease prevention and...
7.
Porrini M, Zachariae U, Barran P, MacPhee C
J Phys Chem Lett
. 2015 Aug;
4(8):1233-8.
PMID: 26282135
Amyloid fibrils are self-assembled aggregates of polypeptides that are implicated in the development of several human diseases. A peptide derived from amino acids 105-115 of the human plasma protein transthyretin...
8.
DAtri V, Porrini M, Rosu F, Gabelica V
J Mass Spectrom
. 2015 Aug;
50(5):711-26.
PMID: 26259654
Ion mobility spectrometry experiments allow the mass spectrometrist to determine an ion's rotationally averaged collision cross section Ω(EXP). Molecular modelling is used to visualize what ion three-dimensional structure(s) is(are) compatible...
9.
Mendoza O, Porrini M, Salgado G, Gabelica V, Mergny J
Chemistry
. 2015 Mar;
21(18):6732-9.
PMID: 25820943
DNA and RNA G-quadruplexes (G4) are unusual nucleic acid structures involved in a number of key biological processes. RNA G-quadruplexes are less studied although recent evidence demonstrates that they are...
10.
Harvey S, Porrini M, Tyler R, MacPhee C, Volkman B, Barran P
Phys Chem Chem Phys
. 2015 Mar;
17(16):10538-50.
PMID: 25805055
Ion mobility mass spectrometry can be combined with data from top-down sequencing to discern adopted conformations of proteins in the absence of solvent. This multi-technique approach has particular applicability for...