Brian F Volkman
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Explore the profile of Brian F Volkman including associated specialties, affiliations and a list of published articles.
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203
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5736
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Recent Articles
1.
Luis R, Volkman B, Szpakowska M, Chevigne A
J Leukoc Biol
. 2025 Feb;
PMID: 39903605
Atypical chemokine receptors (ACKRs) are a subfamily of important regulators of chemokine functions. Among them, ACKR2 has long been considered as a scavenger of multiple inflammatory chemokines exclusively from the...
2.
Syed M, Dishman A, Volkman B, Walker T
Protein Sci
. 2025 Jan;
34(2):e70032.
PMID: 39840812
The chemokine XC motif chemokine ligand 1 (XCL1) is an unusually specialized member of a conserved family of around 50 small, secreted proteins that are best known for their ability...
3.
Zhang B, Harrison K, Zhong Y, Maxwell J, Ford D, Calvey L, et al.
J Am Chem Soc
. 2024 Dec;
146(50):34253-34259.
PMID: 39629944
Chemokines are small proteins involved in recruiting leukocytes to sites of inflammation via interactions with specific cell surface receptors. CCL22 is a chemokine known to play a critical role in...
4.
Perez Almeria C, Otun O, Schlimgen R, Lamme T, Crudden C, Youssef N, et al.
bioRxiv
. 2024 Nov;
PMID: 39574661
Chemokine stimulation of atypical chemokine receptor 3 (ACKR3) does not activate G proteins but recruits arrestins. It is a chemokine scavenger that indirectly influences responses by restricting the availability of...
5.
Zhang X, Schlimgen R, Singh S, Tomani M, Volkman B, Zhang C
Proc Natl Acad Sci U S A
. 2024 Nov;
121(48):e2405732121.
PMID: 39565315
The X-C motif chemokine receptor XCR1, which selectively binds to the chemokine XCL1, is highly expressed in conventional dendritic cells subtype 1 (cDC1s) and crucial for their activation. Modulating XCR1...
6.
Xu T, Schou A, Lackman J, Barrio-Calvo M, Verhallen L, Goth C, et al.
Int J Mol Sci
. 2024 Oct;
25(19).
PMID: 39409188
The chemokine receptors CCR1 and CCR5 display overlapping expression patterns and ligand dependency. Here we find that ligand activation of CCR5, not CCR1, is dependent on N-terminal receptor O-glycosylation. Release...
7.
Shi Z, Mabuchi T, Riutta S, Wu X, Peterson F, Volkman B, et al.
J Psoriasis Psoriatic Arthritis
. 2024 Sep;
8(3):107-117.
PMID: 39296310
Background: Chemokines represent a superfamily of immune-modulatory small protein molecules that regulate leukocyte migration to inflammatory sites through their chemoattractant and cell signaling properties. This review focuses on the immunological...
8.
Pontejo S, Martinez S, Zhao A, Barnes K, de Anda J, Alimohamadi H, et al.
bioRxiv
. 2024 Aug;
PMID: 39091850
Classically, chemokines coordinate leukocyte trafficking during immune responses; however, many chemokines have also been reported to possess direct antibacterial activity in vitro. Yet, the bacterial killing mechanism of chemokines and...
9.
Schlimgen R, Peterson F, Heukers R, Smit M, McCorvy J, Volkman B
Nat Commun
. 2024 May;
15(1):4611.
PMID: 38816420
G protein-coupled receptors (GPCRs) are pivotal therapeutic targets, but their complex structure poses challenges for effective drug design. Nanobodies, or single-domain antibodies, have emerged as a promising therapeutic strategy to...
10.
Jorge S, Chi Y, Lizarraga Mazaba J, Haque N, Wagenknecht J, Smith B, et al.
Front Genet
. 2023 Dec;
14:1291307.
PMID: 38090150
Kleefstra Syndrome type 2 (KLEFS-2) is a genetic, neurodevelopmental disorder characterized by intellectual disability, infantile hypotonia, severe expressive language delay, and characteristic facial appearance, with a spectrum of other distinct...