Massimiliano Gasparrini
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Explore the profile of Massimiliano Gasparrini including associated specialties, affiliations and a list of published articles.
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65
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1512
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Recent Articles
1.
Gasparrini M, Giovannuzzi S, Nocentini A, Raffaelli N, Supuran C
Expert Opin Ther Pat
. 2024 Jun;
34(7):565-582.
PMID: 38861278
Introduction: Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the biosynthesis of nicotinamide adenine dinucleotide (NAD) from nicotinamide. In addition to its role as essential redox cofactor, NAD also functions...
2.
Ponzone L, Audrito V, Landi C, Moiso E, Levra Levron C, Ferrua S, et al.
Mol Cancer
. 2024 May;
23(1):105.
PMID: 38755661
Background: The main drawback of BRAF/MEK inhibitors (BRAF/MEKi)-based targeted therapy in the management of BRAF-mutated cutaneous metastatic melanoma (MM) is the development of therapeutic resistance. We aimed to assess in...
3.
Gasparrini M, Mazzoni L
Int J Mol Sci
. 2024 Apr;
25(7).
PMID: 38612380
Inflammatory bowel diseases (IBD) comprise chronic debilitating inflammatory disorders that can affect different parts of the gastrointestinal tract and are commonly correlated to two main diseases: Crohn's disease (CD) and...
4.
Baldassarri C, Giorgioni G, Piergentili A, Quaglia W, Fontana S, Mammoli V, et al.
Pharmaceuticals (Basel)
. 2023 Jun;
16(2).
PMID: 37259338
The prevention of nicotinamide adenine dinucleotide (NAD) biosynthesis is considered an attractive therapeutic approach against cancer, considering that tumor cells are characterized by an increased need for NAD to fuel...
5.
Minazzato G, Marangoni E, Fortunato C, Petrelli R, Cappellacci L, Del Bello F, et al.
Molecules
. 2023 Feb;
28(3).
PMID: 36770640
The maintenance of a proper NAD pool is essential for cell survival, and tumor cells are particularly sensitive to changes in coenzyme levels. In this view, the inhibition of NAD...
6.
Llobet Rosell A, Paglione M, Gilley J, Kocia M, Perillo G, Gasparrini M, et al.
Elife
. 2022 Dec;
11.
PMID: 36476387
Axon degeneration contributes to the disruption of neuronal circuit function in diseased and injured nervous systems. Severed axons degenerate following the activation of an evolutionarily conserved signaling pathway, which culminates...
7.
Minazzato G, Gasparrini M, Heroux A, Sernova N, Rodionov D, Cianci M, et al.
J Struct Biol
. 2022 Nov;
214(4):107917.
PMID: 36332744
Nicotinamide-adenine dinucleotide (NAD) is centrally important to metabolic reactions that involve redox chemistry. In bacteria, NAD biosynthesis is controlled by different transcription factors, depending on the species. Among the four...
8.
Foligni R, Mannozzi C, Gasparrini M, Raffaelli N, Zamporlini F, Tejada L, et al.
Food Res Int
. 2022 Jul;
158:111592.
PMID: 35840266
In Western and Central Mediterranean countries proteases from wild herbaceous perennial plants commonly known as "thistles" have been used as milk coagulants in cheese-making for centuries. For the first time,...
9.
Cianci M, Giacche N, Cialabrini L, Carotti A, Liscio P, Rosatelli E, et al.
Front Mol Biosci
. 2022 Apr;
9:834700.
PMID: 35463964
Human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) stands at a branch point of the NAD synthesis pathway and plays an important role in maintaining NAD homeostasis. It has been recently identified as a...
10.
Gasparrini M, Audrito V
Int J Biochem Cell Biol
. 2022 Feb;
145:106189.
PMID: 35219878
Nicotinamide phosphoribosyltransferase (NAMPT) possesses a vital role in mammalian cells due to its activity as a rate-limiting enzyme in the biosynthesis of nicotinamide adenine dinucleotide (NAD) from nicotinamide. NAD is...