Masaki Otagiri
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Explore the profile of Masaki Otagiri including associated specialties, affiliations and a list of published articles.
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330
Citations
4020
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Recent Articles
1.
Watabe Y, Chuang V, Sakai H, Ito C, Enoki Y, Kohno M, et al.
Biochem Pharmacol
. 2025 Jan;
233:116782.
PMID: 39880317
Sepsis is a life-threatening condition caused by severe infection and often complicates acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) due to the collapse of the oxidative and...
2.
Adachi T, Tomita Y, Mizukai Y, Maezaki Y, Kawano K, Commey K, et al.
Carbohydr Res
. 2024 Nov;
547:109308.
PMID: 39549317
In this study, we prepared granulated chitosan (G-CS)/catechin tablets with excellent disintegration properties. We then compared their physical properties, dissolution behavior, and pharmacokinetic profile to non-granulated chitosan (N-CS)/catechin tablets. During...
3.
Nishi K, Arimura Y, Suetsugi N, Beppu T, Takasaki K, Tamori A, et al.
Biomed Rep
. 2024 Sep;
21(5):159.
PMID: 39268409
Nitric oxide (NO) has been reported to have a cytotoxic effect on various types of cancer. However, the efficient delivery of NO donors to tumors remains challenging. The present study...
4.
Nishi K, Kanda R, Takasaki K, Tamori A, Arimura Y, Imoto S, et al.
Anticancer Res
. 2024 Aug;
44(9):3793-3798.
PMID: 39197907
Background/aim: Nitric oxide (NO) has various physiological activities. In this study, diclofenac (DF) which has a high affinity for human serum albumin (HSA) was nitrosylated to a novel NO donor...
5.
Yanagisawa H, Maeda H, Noguchi I, Tanaka M, Wada N, Nagasaki T, et al.
Redox Biol
. 2024 Aug;
76:103314.
PMID: 39163766
Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive form of nonalcoholic fatty liver disease characterised by fat accumulation, inflammation, oxidative stress, fibrosis, and impaired liver regeneration. In this study, we found...
6.
Taguchi K, Hashimoto M, Tokuno M, Takeoka S, Maruyama T, Yamasaki K, et al.
Xenobiotica
. 2024 Aug;
54(9):624-628.
PMID: 39087517
In the process of the drug development, studies on the cytochrome P450 (CYP) profiles after its administration provided fundamental information regarding drug interactions with concomitantly administered drugs. Here, we evaluated...
7.
Kawai A, Yamasaki K, Otagiri M, Doi Y
J Med Chem
. 2024 Jul;
67(16):14175-14183.
PMID: 39083648
Modification of the R1 and R2 side chain structures has been used as the main strategy to expand the spectrum of cephalosporins and impart resistance to hydrolysis by β-lactamases. These...
8.
Commey K, Enaka A, Nakamura R, Yamamoto A, Tsukigawa K, Nishi K, et al.
Toxins (Basel)
. 2024 Jul;
16(7).
PMID: 39057956
The characteristic accumulation of circulating uremic toxins, such as indoxyl sulfate (IS), in chronic kidney disease (CKD) further exacerbates the disease progression. The gut microbiota, particularly gut bacterial-specific enzymes, represents...
9.
Noguchi I, Maeda H, Kobayashi K, Nagasaki T, Kato H, Yanagisawa H, et al.
Free Radic Biol Med
. 2024 Apr;
220:67-77.
PMID: 38657755
Sarcopenia is characterized by loss of muscle strength and muscle mass with aging. The growing number of sarcopenia patients as a result of the aging population has no viable treatment....
10.
Taguchi K, Ogaki S, Maeda H, Ishima Y, Watanabe H, Otagiri M, et al.
Biol Pharm Bull
. 2024 Apr;
47(4):868-871.
PMID: 38644197
Restoration of blood flow in skeletal muscle after a prolonged period of ischemia induces muscular ischemia-reperfusion injury, leading to local injury/dysfunction in muscles followed by systemic inflammatory responses. However, preventive/curative...