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Masaki Hikida

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Recent Articles
11.
Todo K, Koga O, Nishikawa M, Hikida M
Sci Rep . 2015 Aug; 5:12208. PMID: 26244941
No abstract available.
12.
Todo K, Koga O, Nishikawa M, Hikida M
Sci Rep . 2015 May; 5:10303. PMID: 25980548
The positive and negative selection of antigen-reactive B cells take place in the germinal center (GC) during an immune responses. However, the precise molecular mechanisms underlying these selection machineries, including...
13.
Shiheido H, Kitagori K, Sasaki C, Kobayashi S, Aoyama T, Urata K, et al.
Immun Inflamm Dis . 2014 Nov; 2(1):35-43. PMID: 25400923
BEN domain-containing protein 3 (BEND3) has no transmembrane region, is localized in the cytoplasm, and is involved in chromatin function and transcription. We here identified a novel subpopulation of human...
14.
Shiheido H, Chen C, Hikida M, Watanabe T, Shimizu J
PLoS One . 2014 Apr; 9(4):e94324. PMID: 24710513
The agonistic anti-human CD3ε antibody (Ab), OKT3, has been used to control acute transplant rejection. The in vivo administration of OKT3 was previously shown to induce the partial depletion of...
15.
Shiheido H, Aoyama T, Takahashi H, Hanaoka K, Abe T, Nishida E, et al.
Eur J Immunol . 2014 Mar; 44(6):1770-80. PMID: 24595757
The activation of T cells is known to be accompanied by the temporary downmodulation of the TCR/CD3 complex on the cell surface. Here, we established a novel monoclonal antibody, Dow2,...
16.
Todo K, Koga O, Nishikawa M, Hikida M
Biochem Biophys Res Commun . 2014 Feb; 445(3):572-7. PMID: 24548411
It has been shown that cytoplasmic tail of the IgG1 B cell receptors (BCRs) are essential for the induction of T-dependent immune responses. Also it has been revealed that unique...
17.
Lores P, Vernet N, Kurosaki T, van de Putte T, Huylebroeck D, Hikida M, et al.
Dev Biol . 2013 Dec; 386(2):419-27. PMID: 24355749
MgcRacGAP (RACGAP1) is a GTPase Activating Protein (GAP), highly produced in the mouse embryonic brain and in the human and mouse post-natal testis. MgcRacGAP negatively controls the activity of Rac...
18.
Capietto A, Kim S, Sanford D, Linehan D, Hikida M, Kumosaki T, et al.
J Exp Med . 2013 Oct; 210(11):2257-71. PMID: 24127488
Myeloid-derived suppressor cells (MDSCs) favor tumor promotion, mainly by suppressing antitumor T cell responses in many cancers. Although the mechanism of T cell inhibition is established, the pathways leading to...
19.
Kim B, Takeuchi A, Koga O, Hikida M, Matsuoka S
Adv Exp Med Biol . 2012 Dec; 961:193-201. PMID: 23224880
Mitochondria Na(+)-Ca(2+) exchange (NCX(mit)) was first discovered by Carafoli et al. in 1974. Thereafter, the mechanisms and roles of NCX(mit) have been extensively studied. We review NCX(mit) in cardiomyocytes and...
20.
Kaji T, Ishige A, Hikida M, Taka J, Hijikata A, Kubo M, et al.
J Exp Med . 2012 Oct; 209(11):2079-97. PMID: 23027924
One component of memory in the antibody system is long-lived memory B cells selected for the expression of somatically mutated, high-affinity antibodies in the T cell-dependent germinal center (GC) reaction....